Development of In-Tether Carbon Chiral Center-Induced Helical Peptide
Methodology and Applications
Seiten
2021
|
1st ed. 2021
Springer Verlag, Singapore
978-981-336-612-1 (ISBN)
Springer Verlag, Singapore
978-981-336-612-1 (ISBN)
This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs.
Introduction.- Method to construct in-tether chiral center constrained helical peptide.- Application in disrupting p53/MDM2 protein-protein interactions.- Fabrication of nanomaterials with in-tether chiral center constrained helical peptide.
| Erscheinungsdatum | 29.01.2021 |
|---|---|
| Reihe/Serie | Springer Theses |
| Zusatzinfo | 65 Illustrations, color; 10 Illustrations, black and white; XV, 102 p. 75 illus., 65 illus. in color. |
| Verlagsort | Singapore |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Technik ► Maschinenbau | |
| Schlagworte | Cell permeability • chirality • Helicity • protein-protein interactions • Self-Assembly • Stabilized peptide • Staple peptide |
| ISBN-10 | 981-336-612-5 / 9813366125 |
| ISBN-13 | 978-981-336-612-1 / 9789813366121 |
| Zustand | Neuware |
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