Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis

George G. Harrigan, Royston Goodacre (Herausgeber)

Buch | Hardcover

335 Seiten

2003
Springer-Verlag New York Inc.
978-1-4020-7370-0 (ISBN)

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It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.

1. Introduction.- 2. Metabolome And Proteome Profiling For Microbial Characterization.- 3. Can 1H NMR Derived Metabolic Profiles Contribute To Proteomic Analyses?.- 4. Application Of Metabonomics In The Pharmaceutical Industry.- 5. Metabolic Profiling In Tumors By In Vivo And In Vitro NMR Spectroscopy.- 6. Raman Spectroscopy For Whole Organism And Tissue Profiling.- 7.Metabolic Fingerprinting With Fourier Transform Infrared Spectroscopy.- 8.Metabolomic Analysis With Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.- 9.Stable Isotope-Based Dynamic Metabolic Profiling In Disease And Health.- 10. The Role Of Metabolomics In Systems Biology.- 11. Use Of Metabolomics To Discover Metabolic Patterns Associated With Human Diseases.- 12. Bioactive Lipids In Reproductive Diseases.- 13. Evolutionary Computation For The Interpretation Of Metabolomic Data.- 14. Dynamic Profiling And Canonical Modeling.- 15. Databases, Data Modeling And Schemas.- 16. Databases And Visualization For Metabolomics.- 17. The Human Metabolomics.

Erscheint lt. Verlag	31.1.2003
Zusatzinfo	XIV, 335 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Chemie ► Analytische Chemie
	Technik
ISBN-10	1-4020-7370-4 / 1402073704
ISBN-13	978-1-4020-7370-0 / 9781402073700
Zustand	Neuware