Peptide and Protein Engineering

From Concepts to Biotechnological Applications

Olga Iranzo, Ana Cecília Roque (Herausgeber)

Buch | Hardcover

289 Seiten

2020 | 1st ed. 2020
Springer-Verlag New York Inc.
978-1-0716-0719-0 (ISBN)

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This thorough book aims to present the methods that have enabled the success of peptides and proteins in a wide variety of applications. It opens with a section on chemical tools applied to the production or engineering of peptides and proteins, and concludes with a collection of chapters on biological approaches used to engineer structure and function in peptides and proteins. As a book in the Springer Protocols Handbooks series, chapters include the kind of detailed descriptions and tips necessary for successful results in practice.
Authoritative and practical, Peptide and Protein Engineering: From Concepts to Biotechnological Applications will be of great use to scientists in academia and industry seeking a better understanding of the emerging principles and methodologies in peptide and protein engineering.

SEA Ligation is Accelerated at Midly Acidic pH: Application to the Formation of Difficult Peptide Junctions.- The Problem of Aspartimide Formation during Protein Chemical Synthesis Using SEA-Mediated Ligation.- Using the Interactive Tool of the Protein Chemical Synthesis Database.- Only a “Click” Away: Development of Arginine-Rich Peptide-Based Materials Using Click Chemistry.- Fluoroglycoproteins by Copper-Free Strain-Promoted Azide–Alkyne Cycloaddition.- Hybrid Silylated Peptides for the Design of Bio-Functionalized Materials.- Synthesis of Peptide-Oligoethylene Glycol (OEG) Conjugates for Multivalent Modification of Nanomaterials.- Phage Display Methodologies.- Whole-Bacterium Ribosome Display Selection for Isolation of Anti-Bacterial Affitins.- CIS Display: DNA-Based Technology as a Platform for Discovery of Therapeutic Biologics.- Building Scarless Gene Libraries in the Chromosome of Bacteria.- Streptavidin (Sav)-Based Artificial Metalloenzymes: Cofactor Design Considerations and Large Scale Expression of Host Protein Variants.- Integrated Bacterial Production of Large Combinatorial Libraries of Cyclic Oligopeptides and Functional Screening for the Identification of Chemical Rescuers of Pathogenic Protein Misfolding and Aggregation.- Site-Specific Incorporation of Non-Canonical Amino Acids by Amber Stop Codon Suppression in Escherichia coli.

Erscheinungsdatum	31.07.2020
Reihe/Serie	Springer Protocols Handbooks
Zusatzinfo	54 Illustrations, color; 17 Illustrations, black and white; XI, 289 p. 71 illus., 54 illus. in color.
Verlagsort	New York, NY
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Chemie ► Technische Chemie
	Technik
Schlagworte	Biocatalysis • chemical modification • Chemical tools • Diagnostics • Molecular engineering • Protein production • Structure engineering • therapeutics
ISBN-10	1-0716-0719-7 / 1071607197
ISBN-13	978-1-0716-0719-0 / 9781071607190
Zustand	Neuware