Pharmacogenomics of Human Drug Transporters (eBook)

Clinical Impacts

Toshihisa Ishikawa, Richard B. Kim, Jörg König (Autoren)

eBook Download: EPUB

2013 | 1. Auflage
440 Seiten
John Wiley & Sons (Verlag)
978-1-118-35325-7 (ISBN)

Infos

Sets the foundation for safer, more effective drug
therapies

With this book as their guide, readers will discover how to
apply our current understanding of the pharmacogenomics of drug
transporters to advance their own drug discovery and development
efforts. In particular, the book explains how new findings in the
field now enable researchers to more accurately predict drug
interactions and adverse drug reactions. Moreover, it sets the
foundation for the development of drug therapies that are tailored
to an individual patient's genetics.

Pharmacogenomics of Human Drug Transporters serves as a
comprehensive guide to how transporters regulate the absorption,
distribution, and elimination of drugs in the body as well as how
an individual's genome affects those processes. The book's eighteen
chapters have been authored by a team of leading pioneers in the
field. Based on their own laboratory and clinical experience as
well as a thorough review of the literature, these authors explore
all facets of drug transporter pharmacogenomics, including:

* Individual drug transporters and transporter families and their
clinical significance

* Principles of altered drug transport in drug-drug
interactions, pharmacotherapy, and personalized medicine

* Emerging new technologies for rapid detection of genetic
polymorphisms

* Clinical aspects of genetic polymorphisms in major drug
transporter genes

* Future research directions of drug transporter pharmacogenomics
and the prospect of individualized medicine

Pharmacogenomics of Human Drug Transporters opens the
door to new drug discovery and development breakthroughs leading to
safer and more effective customized drug therapies.The book is
recommended for pharmaceutical scientists, biochemists,
pharmacologists, clinicians, and genetics and genomics
researchers.

Autor

TOSHIHISA ISHIKAWA, PhD, is Senior Scientist at RIKEN Yokohama Institute and Professor of Biochemistry, Molecular Biology, and Pharmacogenomics at Yokohama City University's Graduate School of Medicine. Previously, Dr. Ishikawa was the Director of the Department of Research Technology Development at Pfizer, Japan. A recipient of the Achievement Award from the International Life Sciences Institute (ILSI), Dr. Ishikawa is also the cofounder of the International Transporter Consortium (ITC). RICHARD B. KIM, MD, FRCPC, is Professor and Chair of the Division of Clinical Pharmacology and Associate Chair for Research in the Department of Medicine at the University of Western Ontario. He is a Fellow of the American Association of Pharmaceutical Scientists and an elected member of the American Society for Clinical Investigation. JÖRG KÖNIG, PhD, is Professor and Head of the Molecular Biology Laboratories in the Department of Clinical Pharmacology at the Friedrich-Alexander Universität Erlangen-Nürnberg.

Inhalt

PREFACE vii

CONTRIBUTORS ix

CHAPTER 1 INTRODUCTION TO PHARMACOGENOMICS OF DRUG TRANSPORTERS
1

Marianne K. DeGorter and Richard B. Kim

CHAPTER 2 ADME PHARMACOGENOMICS IN DRUG DEVELOPMENT 13

Liangfu Chen and Joseph W. Polli

CHAPTER 3 REGULATORY PERSPECTIVE ON PHARMACOGENOMICS OF
DRUG-METABOLIZING ENZYMES AND TRANSPORTERS 39

Lei Zhang, Gilbert J. Burckart, Lawrence J. Lesko and Shiew-Mei
Huang

CHAPTER 4 THE PHARMACOGENOMICS OF MEMBRANE TRANSPORTERS PROJECT
73

Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini

CHAPTER 5 EMERGING NEW TECHNOLOGY OF SNP TYPING 109

Toshihisa Ishikawa and Yoshihide Hayashizaki

CHAPTER 6 OATP1A2, OAT1, AND OAT3 125

Rommel G. Tirona

CHAPTER 7 OATP1B1, OATP1B3, AND OATP2B1 141

J¨org K¨onig and Martin F. Fromm

CHAPTER 8 OCT (SLC22A) AND OCTN FAMILY 171

Sophie L. Stocker, Arian Emami Riedmaier, Matthias Schwab and
Kathleen M. Giacomini

CHAPTER 9 MATE (SLC47) FAMILY 209

Atsushi Yonezawa and Ken-ichi Inui

CHAPTER 10 PEPT (SLC15A) FAMILY 223

Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato

CHAPTER 11 NUCLEOSIDE TRANSPORTERS (SLC28 AND SLC29) FAMILY
243

M´yriam Molina-Arcas and Marc¸al
Pastor-Anglada

CHAPTER 12 P-GLYCOPROTEIN (MDR1/ABCB1) 271

Ingolf Cascorbi

CHAPTER 13 BSEP (ABCB11) 295

Bruno Stieger and Gerd A. Kullak-Ublick

CHAPTER 14 BCRP (ABCG2) 311

Agnes Basseville, Susan E. Bates, William D. Figg and Alex
Sparreboom

CHAPTER 15 MRP2 (ABCC2) AND MRP3 (ABCC3) 345

Anne T. Nies

CHAPTER 16 MRP4 (ABCC4) 365

Satish B. Cheepala, Mugdha Sukthankar and John D.
Schuetz

CHAPTER 17 MRP8 (ABCC11) 387

Yu Toyoda and Toshihisa Ishikawa

CHAPTER 18 FUTURE PERSPECTIVES 401

Toshihisa Ishikawa and Joseph Ware

INDEX 417

Produkt-Details

• Erscheint lt. Verlag: 11.3.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Technik ► Umwelttechnik / Biotechnologie
• Schlagworte: Biowissenschaften • Chemie • Chemistry • Drug Discovery & Development • Life Sciences • Medical Science • Medizin • molecular genetics • Molekulargenetik • Pharmacology & Pharmaceutical Medicine • Pharmakologie • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung
• ISBN-10: 1-118-35325-0 / 1118353250
• ISBN-13: 978-1-118-35325-7 / 9781118353257