Legionella Pneumophila: Pathogenesis and Immunity (eBook)

Paul Hoffman, Herman Friedman, Mauro Bendinelli (Herausgeber)

eBook Download: PDF

2007 | 2008
XVIII, 208 Seiten
Springer US (Verlag)
978-0-387-70896-6 (ISBN)

Infos

The volume brings together all of the latest research on this pathogen, the interest in which is rapidly growing. Legionella pneumophila is an emerging human pathogen that resides in natural environments as a parasite of freshwater. There have been major new developments in this field, including the publication of three whole genome sequences and the discovery of a developmental cycle and novel cyst-like highly infectious form.

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Legionella pneumophila is an emerging human pathogen that resides in natural environments as a parasite of freshwater. There have been new developments in this field including the publication of three whole genome sequences, the discovery of a developmental cycle and novel cyst-like highly infectious form, and the bacteria have been used as a probe for macrophage cellular function to unravel fundamental new knowledge in the area of cellular biology. Legionella has also become a model system for the study of innate as well as adaptive immunity. Information on Legionella continues to increase in the U.S. and abroad. Columbia University has started the first Legionella Genome Project with a multi-million dollar grant from the NIH. In addition, The European Working Group for Legionella infections was formed in 1986. Members are scientists with an interest in improving knowledge and information on the clinical and environmental aspects of legionnaires' disease through developments in diagnosis, management and treatment of the disease. The volume brings together all of the lastest research on this pathogen, the interest in which is rapidly growing.

Inhalt

Contents 7
Preface and Introduction 12
Contributors 15
Legionella pneumophila Pathogenesis: Lessons Learned from Genomics 17
Iron Assimilation and Type II Protein Secretion 48
The Dot/Icm Type IVB Secretion System 64
Life Cycle, Growth Cycles and Developmental Cycle of Legionella pneumophila 79
Legionella in the Environment 99
Regulation of the Legionella pneumophila Life Cycle 109
Microbial Physiology 126
LegionnairesÌ DiseaseÛClinical Picture 145
Legionella pneumophila: Innate and Adaptive Immunity 163
Nonspecific Stimulation of Immunity Against Legionella 184
Interaction of Legionella pneumophila with Amoeba 195
Index 213

Produkt-Details

• Erscheint lt. Verlag: 24.10.2007
• Reihe/Serie: Infectious Agents and Pathogenesis
• Reihe/Serie: Infectious Agents and Pathogenesis
• Zusatzinfo: XVIII, 208 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Pneumologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Technik
• Schlagworte: Atmen • Bacteria • Infection • Infections • Infectious • Infectious Diseases • Physiology • Protein
• ISBN-10: 0-387-70896-0 / 0387708960
• ISBN-13: 978-0-387-70896-6 / 9780387708966