Targeting Functional Centers of the Ribosome
Seiten
2011
Springer Berlin (Verlag)
978-3-642-16930-4 (ISBN)
Springer Berlin (Verlag)
978-3-642-16930-4 (ISBN)
This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.
Introduction.- Methods.- Results.- Discussion.
| Erscheint lt. Verlag | 3.2.2011 |
|---|---|
| Reihe/Serie | Springer Theses |
| Zusatzinfo | XIV, 74 p. |
| Verlagsort | Berlin |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 325 g |
| Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Technik ► Maschinenbau | |
| Schlagworte | cross-resistance • Peptidyl Transferase Center • pleuromutilin antibiotics • proto-ribosome • ribosome evolution • RNP (Ribonukleinprotein) |
| ISBN-10 | 3-642-16930-9 / 3642169309 |
| ISBN-13 | 978-3-642-16930-4 / 9783642169304 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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