Metabolomics Perspectives
Academic Press Inc (Verlag)
978-0-323-85062-9 (ISBN)
The philosophy behind the book is to guide the reader in a step-by-step exploration of metabolomics experiments, ranging from sample preparation to data extraction, analysis and interpretation, and to discuss the main current applications and future perspectives of this emerging science.
Armed with critical insights, coupled with a clear writing, the book consists of three main sections. The first one introduces the pivotal theoretical fundamentals and provides a comprehensive overview of the "wet" laboratory workflow, including protocol instructions and a detailed description of experimental methods and analytical techniques. The second section covers a wide range of topics in the context of data analysis, including guidance in exploratory analysis, supervised and unsupervised machine learning approaches and validation and optimization methods. In addition to the several examples reported in the text, the book features an R package, specifically designed to perform all the described algorithms, which is hosted on a companion website (www.metabolomicsperspectives.com) together with several sets of available metabolomic data. Finally, an extensive dissertation describes the latest advances and the major fields of interest for metabolomics applications, highlighting their crucial potentials for future biomedical research.
Thus, this book represents a must-read for both experienced researchers, interested in metabolomics, and newcomers to the field.
Author of more than 100 papers in international peer-reviewed journals, holder of several international patents, and speaker at dozen international conferences, Jacopo Troisi is an award-winning expert in the metabolomics field. After graduating Summa cum Laude in biotechnology, he joined Medical School in the prestigious “Scuola Medica Salernitana at the University of Salerno (Italy). He also attended and completed studies in data analysis. Currently, he is a visiting professor of Metabolomics in both Salerno and Sannio Universities (Italy), cofounder and CEO at Theoreo Srl, spin-off company of the University of Salerno, and COO at the European Biomedical Research Institute of Salerno (EBRIS). His research interests are mainly focused on metabolomic profiling to provide insights in human disease onset and for the development of diagnostic tools.
Part 1 Fundamentals 1. System biology 2. Experimental design in metabolomics 3. Separation techniques 4. Mass spectrometry in metabolomics 5. Nuclear magnetic resonance in metabolomics 6. Targeted metabolomics 7. Approaches in untargeted metabolomics
Part 2 Data analysis 8. Techniques for converting metabolic data for analysis 9. Data analysis in metabolomics: from information to knowledge 10. Relevant metabolites’ selection strategies 11. Pathway analysis
Part 3 Application 12. Cell culture metabolomics and lipidomics 13. Single cell metabolomics 14. Gut microbiota-derived metabolites in host physiology 15. MALDI
| Erscheinungsdatum | 25.03.2022 |
|---|---|
| Zusatzinfo | 280 illustrations (230 in full color); Illustrations |
| Verlagsort | Oxford |
| Sprache | englisch |
| Maße | 191 x 235 mm |
| Gewicht | 450 g |
| Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| ISBN-10 | 0-323-85062-6 / 0323850626 |
| ISBN-13 | 978-0-323-85062-9 / 9780323850629 |
| Zustand | Neuware |
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