Ubiquitin

Proteasome Pathway

Xianquan Zhan (Herausgeber)

Buch | Hardcover

124 Seiten

2020
IntechOpen (Verlag)
978-1-83880-432-9 (ISBN)

Infos

The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases.

Produkt-Details

• Erscheint lt. Verlag: 9.12.2020
• Reihe/Serie: Biochemistry
• Verlagsort: London
• Sprache: englisch
• Maße: 180 x 260 mm
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• ISBN-10: 1-83880-432-3 / 1838804323
• ISBN-13: 978-1-83880-432-9 / 9781838804329
• Zustand: Neuware