Proteostasis and Disease
Springer International Publishing (Verlag)
978-3-030-38265-0 (ISBN)
This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology.
Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
Rosa Barrio obtained her PhD in the Centre of Molecular Biology Severo Ochoa (Madrid, Spain) on the study of ubiquitin genes in Drosophila. Since then, she was interested on the effect of ubiquitin-like molecules on relevant transcription factors involved in organismal development and physiology. After her postdoctoral training at European Molecular Biology Laboratory (Heidelberg, Germany), she is a principal investigator in the Functional Genomics Unit of CIC bioGUNE (Derio, Spain) since December 2004. Using Drosophila as a model system, her laboratory unveiled the role of SUMOylation in vivo in the processes of steroidogenesis through the regulation of the Steroidogenic Factor 1, and development through the regulation of the Spalt-like factors (SALL) and ciliogenesis. The laboratory developed technology for the study posttranslational modifications by members of the ubiquitin family, and apply this technology for the analysis of the ubiquitin code.
Part I. Cancer.- Ubiquitin-Regulated Cell Proliferation and Cancer.- Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer.- The Proteasome System in Health and Disease.- Proteostasis Dysregulation in Pancreatic Cancer.- Divergent Modulation of Proteostasis in Prostate Cancer.- Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma.- Part II. Neurodegeneration.- Altered Proteostasis in Neurodegenerative Tauopathies.- The Ubiquitin System in Alzheimer's Disease.- The Interplay Between Proteostasis Systems and Parkinson's Disease.- Machado-Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides.- Part III. Infection, In ammation and Developmental Disorders.- SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends.- The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication.- By the Tips of Your Cilia: Ciliogenesis in the Retina and the Ubiquitin-Proteasome System.- TRIME3 Ubiquitin Ligases in Rare Genetic Disorders.- Part IV. Diet.- We Are What We Eat: Ubiquitin-Proteasome System (UPS) Modulation Through Dietary Products.
| Erscheinungsdatum | 11.04.2020 |
|---|---|
| Reihe/Serie | Advances in Experimental Medicine and Biology |
| Zusatzinfo | XII, 348 p. 42 illus., 24 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 178 x 254 mm |
| Gewicht | 874 g |
| Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
| Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Schlagworte | autophagy • Cancer • Development • inflammation • Neurodegeneration • Physiology • protein homeostasis • proteostasis • Rare Disease • Ubiquitin • Ubiquitin-likes |
| ISBN-10 | 3-030-38265-6 / 3030382656 |
| ISBN-13 | 978-3-030-38265-0 / 9783030382650 |
| Zustand | Neuware |
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