Vitamin-Dependent Multienzyme Complexes of 2-Oxo Acid Dehydrogenases

Structure, Function, Regulation & Medical Implications

Victoria Bunik (Autor)

Buch | Hardcover

160 Seiten

2017
Nova Science Publishers Inc (Verlag)
978-1-5361-2166-7 (ISBN)

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This book summarises current data on the architecture, structure-function relationships, reaction mechanisms and active site coupling in multienzyme complexes of 2-oxo acid dehydrogenases. Special focus concerns the mechanisms of function and regulation of a multienzyme structure, additional to those inherent in its component enzymes. The overall physiological process of 2-oxo acid oxidative decarboxylation and the substrate specificity determinants are considered along with side reactions of regulatory significance, such as non-oxidative reactions, formation of reactive oxygen species (ROS) and complex-bound thiyl radicals. The significance of the chemical interplay between the complex-bound dihydrolipoate intermediate, thioredoxin or thioredoxin-like proteins, and peroxiredoxins for sensing metabolic state and adjusting the catalysis accordingly, is considered. Other mechanisms involved in the short- and long-term regulation of 2-oxo acid dehydrogenase complexes are summarized in view of their relevance to physiological functions. Metabolic regulation by natural effectors of 2-oxo acid dehydrogenase complexes and their synthetic analogues is considered. The medical implications of enzymological knowledge on the complexes are also presented.

Preface; Introduction; Principles of Self-Assembly of 2-Oxo Acid Dehydrogenase Complexes; Catalytic Mechanism of Physiological 2-Oxo Acid Dehydrogenase Reaction; Side Reactions Catalysed by 2-Oxo Acid Dehydrogenase Complexes; Functional Significance of Variable Component Stoichiometry of 2-Oxo Acid Dehydrogenase Complexes; Principles of Regulation of 2-Oxo Acid Dehydrogenase complexes; Medical Implications of 2-Oxo Acid Dehydrogenase Complexes; Conclusion; References; Index.

Erscheinungsdatum	13.09.2017
Verlagsort	New York
Sprache	englisch
Maße	155 x 230 mm
Gewicht	430 g
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-5361-2166-5 / 1536121665
ISBN-13	978-1-5361-2166-7 / 9781536121667
Zustand	Neuware