Regulation of Cytokine Gene Expression in Immunity and Diseases (eBook)
VIII, 225 Seiten
Springer Netherlands (Verlag)
978-94-024-0921-5 (ISBN)
This book explores the major cytokines, such as IL-1 and IFN-γ, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.
Dr. Xiaojing Ma is a professor from Department of Microbiology and Immunology, Weill Cornell Medical College, USA. He is also the chair professor and associate dean of School of Life Sciences and Biotechnology, Shanghai Jiao Tong University. He serves as the associate editor of The Journal of Immunology, and is in the editorial board of several international journals, such as The Journal of Experimental Medicine, Annual Review of Biomedical Science and Cellular and Molecular Immunology. His research focuses on molecular regulation of cytokine gene expression and their immunological activities in inflammatory diseases, and he has published more than 80 research articles on top journals in this field.
This book explores the major cytokines, such as IL-1 and IFN-y, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presentingcutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.
Dr. Xiaojing Ma is a professor from Department of Microbiology and Immunology, Weill Cornell Medical College, USA. He is also the chair professor and associate dean of School of Life Sciences and Biotechnology, Shanghai Jiao Tong University. He serves as the associate editor of The Journal of Immunology, and is in the editorial board of several international journals, such as The Journal of Experimental Medicine, Annual Review of Biomedical Science and Cellular and Molecular Immunology. His research focuses on molecular regulation of cytokine gene expression and their immunological activities in inflammatory diseases, and he has published more than 80 research articles on top journals in this field.
Regulation of IFN-γ expression.- Regulation of The interleukin-1 family.- Regulation of IL-4 Expression in Immunity and Diseases.- Regulation of IL-6 in immunity and diseases.- Regulation of Interleukin-10 Expression.- Regulation of Interleukin-12 Production in Antigen-Presenting Cells.- Regulation of Interleukin-17 production.- Regulation of interleukin-23 expression in health and disease.- Regulation and immune function of IL-27.- The immunobiology of Interleukin-35 and its regulation and gene expression
| Erscheint lt. Verlag | 12.10.2016 |
|---|---|
| Reihe/Serie | Advances in Experimental Medicine and Biology | Advances in Experimental Medicine and Biology |
| Zusatzinfo | VIII, 225 p. 23 illus., 22 illus. in color. |
| Verlagsort | Dordrecht |
| Sprache | englisch |
| Themenwelt | Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| Naturwissenschaften ► Biologie | |
| Technik | |
| Schlagworte | autoimmunity • Cytokine • Epigenetic regulation • gene expression • immunity • Infection |
| ISBN-10 | 94-024-0921-1 / 9402409211 |
| ISBN-13 | 978-94-024-0921-5 / 9789402409215 |
| Haben Sie eine Frage zum Produkt? |
PDF (Wasserzeichen)Größe: 5,4 MB
DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasserzeichen und ist damit für Sie personalisiert. Bei einer missbräuchlichen Weitergabe des eBooks an Dritte ist eine Rückverfolgung an die Quelle möglich.
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich
