DNA Topology
Oxford University Press (Verlag)
978-0-19-963349-4 (ISBN)
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The structure of the DNA double helix has been recognized for many years but, more recently, the existence and biological importance of different conformations of DNA have become known, the most prominent being the "topological" deformations such as supercoiling and catenation. Almost all biological processes involving DNA, such as replication, recombination, and transcription, have effects on, and are affected by, the topological state of the DNA. This book provides explanations of these concepts in their biological contexts, making it a useful text for students of molecular biology, biochemistry and related disciplines, and for researchers in the field.
Part 1 DNA structure: DNA structures; alternative DNA structures; intrinsic curvature and DNA bending. Part 2 DNA supercoiling: historical perspective; geometric properties of closed-circular DNA; topology and geometry of real DNA; thermodynamics of DNA supercoiling; biological effects of supercoiling free energy. Part 3 DNA on surfaces: the helical repeat of DNA; the surface linking treatment; the nucleosome. Part 4 Knots and catenanes: knots; catenanes; knots and catenanes as probes of DNA - protein interactions. Part 5 DNA topoisomevases: reactions of topoisomevases; mechanism of topoisomevases; topoisomevases as drug targets; biological role of topoisomevases. Part 6 Biological consequences of DNA topology: introduction - the ubiquity of DNA supercoiling; genome organization; transcription the twin supercoiled domain model; control of gene expression; replication; recanbination.
| Erscheint lt. Verlag | 30.4.1993 |
|---|---|
| Reihe/Serie | In Focus |
| Zusatzinfo | halftones, line drawings, bibliography |
| Verlagsort | Oxford |
| Sprache | englisch |
| Maße | 150 x 230 mm |
| Gewicht | 224 g |
| Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| ISBN-10 | 0-19-963349-5 / 0199633495 |
| ISBN-13 | 978-0-19-963349-4 / 9780199633494 |
| Zustand | Neuware |
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