Chemokines

Chemokines and Their Receptors in Drug Discovery

Buch | Hardcover

VII, 245 Seiten

2015 | 2015
Springer International Publishing (Verlag)
978-3-319-14059-9 (ISBN)

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Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Introduction.- Insights in the chemokine receptor structures and drug design approaches in chemokine receptors.- Therapeutic targeting of CXCR3 chemokine receptor by small molecules.- Allosteric modulation of chemokine receptors.- Chemokines and their receptors in CNS.- Chemokine receptors in allergy and inflammation

Erscheint lt. Verlag	24.3.2015
Reihe/Serie	Topics in Medicinal Chemistry
Zusatzinfo	VII, 245 p. 380 illus., 20 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	549 g
Themenwelt	Medizin / Pharmazie ► Pharmazie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Chemie ► Physikalische Chemie
	Naturwissenschaften ► Chemie ► Technische Chemie
Schlagworte	Allosteric Modulation • Chemokine Receptor Structures • CXCR3 Targeting • drug design • GPCRs • G-Protein Coupled Receptors • Immune Cell Trafficking • receptors • Receptors in Allergy and Inflammation • Therapeutic Targeting
ISBN-10	3-319-14059-0 / 3319140590
ISBN-13	978-3-319-14059-9 / 9783319140599
Zustand	Neuware