Novel Synthetic Chemistry of Ureas and Amides
Seiten
2014
|
2013
Springer Berlin (Verlag)
978-3-642-44890-4 (ISBN)
Springer Berlin (Verlag)
978-3-642-44890-4 (ISBN)
This book explores the chemistry and application of molecules containing urea and amide bonds, fundamental to biological processes. Reviews the author's finding that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions.
In this thesis, the author investigates the chemistry and application of molecules containing urea and amide bonds. These bonds are some of the strongest known and are fundamental to biological processes. The author describes his discovery that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions. This is a remarkable finding, since ureas are inert under these conditions and a general rule of chemistry is that hindered substrates are less reactive. Remarkably, the author translates these results to the correspondingly sterically hindered amides. This thesis has resulted in a number of outstanding publications in high profile journals. The unique method for breaking urea and amide bonds developed in this study is likely to have far reaching consequences for biological protein manipulation.
In this thesis, the author investigates the chemistry and application of molecules containing urea and amide bonds. These bonds are some of the strongest known and are fundamental to biological processes. The author describes his discovery that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions. This is a remarkable finding, since ureas are inert under these conditions and a general rule of chemistry is that hindered substrates are less reactive. Remarkably, the author translates these results to the correspondingly sterically hindered amides. This thesis has resulted in a number of outstanding publications in high profile journals. The unique method for breaking urea and amide bonds developed in this study is likely to have far reaching consequences for biological protein manipulation.
Transition metal catalysis.- Palladium catalysis.- Pd(II) catalysed aminocarbonylation of alkenes.- Carbonylation of aryl ureas.- Urea Hydrolysis.- Amide hydrolysis.
| Erscheint lt. Verlag | 20.9.2014 |
|---|---|
| Reihe/Serie | Springer Theses |
| Zusatzinfo | XVIII, 166 p. |
| Verlagsort | Berlin |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 290 g |
| Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Naturwissenschaften ► Chemie ► Physikalische Chemie | |
| Schlagworte | Amide Hydrolysis • C-H Activation • Mild Solvolysis • Neutral Solvolysis • Palladium Catalysed Carbonylation • Rapid Solvolysis • Urea Hydrolysis |
| ISBN-10 | 3-642-44890-9 / 3642448909 |
| ISBN-13 | 978-3-642-44890-4 / 9783642448904 |
| Zustand | Neuware |
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