Stem Cells in Cancer: Should We Believe or Not? (eBook)

Enrique Grande, Luis Antón Aparicio (Herausgeber)

eBook Download: PDF

2014 | 2014
VIII, 299 Seiten
Springer Netherland (Verlag)
978-94-017-8754-3 (ISBN)

Infos

This volume explores the latest developments in a novel area of molecular biology and a hot topic in the field of oncology: cancer stem cells. These chapters from expert contributing authors present concepts such as the universal stem cell, new molecular pathways, new targeted agents, the different roles that cancer stem cells seem to have according to the organ they are placed in, and the future role that targeting cancer stem cells may have in the management of patients in the clinic.

Exploring the latest research including new data from randomized trials, this book examines important proposals over the origin of cancer stem cells such as the possibility that cancer stem cells may arise from mutated stem cells or a fully differentiated cell that may undergo several mutations that drive it back to a stem-like state. The authors consider the role that stem cells seem to have in the onset, development and resistance to classical antitumoral treatments of cancer and discuss possible potential future treatment modalities for the management of advanced cancer patients.

The question, 'Are stem cells involved in cancer?' may not have a simple answer, but ongoing investigations, in-depth consideration and a broad spectrum of information can be found in this book, allowing the reader to arrive at his or her own answer.

This book will appeal to researchers in the field of oncology and cancer research and biomedical scientists with an interest in stem cells.

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This volume explores the latest developments in a novel area of molecular biology and a hot topic in the field of oncology: cancer stem cells. These chapters from expert contributing authors present concepts such as the universal stem cell, new molecular pathways, new targeted agents, the different roles that cancer stem cells seem to have according to the organ they are placed in, and the future role that targeting cancer stem cells may have in the management of patients in the clinic.Exploring the latest research including new data from randomized trials, this book examines important proposals over the origin of cancer stem cells such as the possibility that cancer stem cells may arise from mutated stem cells or a fully differentiated cell that may undergo several mutations that drive it back to a stem-like state. The authors consider the role that stem cells seem to have in the onset, development and resistance to classical antitumoral treatments of cancer and discuss possible potential future treatment modalities for the management of advanced cancer patients.The question, "e;Are stem cells involved in cancer?"e; may not have a simple answer, but ongoing investigations, in-depth consideration and a broad spectrum of information can be found in this book, allowing the reader to arrive at his or her own answer.This book will appeal to researchers in the field of oncology and cancer research and biomedical scientists with an interest in stem cells.

Inhalt

Foreword  Stem Cells in CancerDr. Jesús García FoncillasChapter 1  The universal stem cell: does it exist?Dr. Guadalupe Aparicio and cols.Chapter 2  What is the meaning of Notch pathway and how we can selectively do the targetingDr. Jorge Barriuso and cols.Chapter 3  Hedhehog as a new paradigm in cancer treatment Stem cells in cancer: should we believe or not?Dr. Pere Gascón and cols. Chapter 4  Wnt pathway at a glance: from the deep of the crypts to the current ways of targetingDr. Alberto Muñoz Terol and cols. Chapter 5  Cancer Stem Cells in Brest CancerDr. Ana LLuch and cols. Chapter 6  Cancer Stem Cells in Colon Cancer Dr. Esther Uña and cols. Chapter 7  Cancer Stem Cells in Genitourinary CancerDr. Luis León and cols. Chapter 8 Cancer Stem Cells in Pancreatic CancerDr. Jorge Guadarrama and cols. Chapter 9  Cancer Stem Cells in Gastric CancerDr. José David Gómez Rangel and cols. Chapter 10  Cancer Stem Cells in MelanomaDr. Ainara SoriaChapter 11  Cancer Stem Cells in Brain TumorsDr. Fernando Hurtado de Mendoza and cols. Chapter 12  Cancer Stem Cells in SarcomasDr. Andrés Cardona and cols. Chapter 13 Cancer Stem Cells in Gynecologic TumorsDr. Juan Carlos Mellidez and cols.

Produkt-Details

• Erscheint lt. Verlag: 28.4.2014
• Zusatzinfo: VIII, 299 p. 23 illus., 19 illus. in color.
• Verlagsort: Dordrecht
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Cancer Biology • Cancer Stem Cells • Hedgehog • Notch • Wnt
• ISBN-10: 94-017-8754-9 / 9401787549
• ISBN-13: 978-94-017-8754-3 / 9789401787543