Purine and Pyrimidine Metabolism in Man VI

Part B: Basic Research and Experimental Biology

Buch | Softcover

552 Seiten

2012 | Softcover reprint of the original 1st ed. 1989
Springer-Verlag New York Inc.
978-1-4684-5678-3 (ISBN)

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These two volumes contain articles presented at the Vlth International Symposium on Human Purine and Pyrimidine Metabolism held in Hakone, Japan, July 17 trough 21, 1988. The first meeting of this series of symposia convened in Tel Aviv, Israel, and since then meetings have taken place every three years in various parts of the world. The second meeting was held in Baden, Austria, the third in Madrid, Spain, the fourth in Maastricht, the Netherlands, and fifth'in San Diego, California. The Vlth meeting in Hakone marked the first such symposium held in Asia. On occasion of publishing these books, I would like to describe how research in this field has evolved in Japan. Early in the 1950s, I was engaged in clinical practice treating various rheumatic diseases as an orthopedicist, and found that a substantial percentage of our patients had symptoms apparently compatible with gout. During the 1960s, the number of these gouty patients increased, and in the 1970s, research on the pathogenesis of gout was performed on the basis of approximately 2,000 cases of this disease, together with precise epidemiological studies concerning gouty and hyperuricemic individuals. Data derived from the two kinds of study had greatly changed the notion that gout was a rare disease among Japanese. My clinical studies have been succeeded by research at the molecular level on various purine metabolic abnormalities, including not only gout but also other diseases with various symptoms of wide clinical spectra.

Biochemistry of Enzymes in Purine and Pyrimidine Metabolism.- Toxic Mechanisms of Deoxynucleosides.- Anti-Cancer Purine and Pyrimidine Analogs, Basic Research.- Anti-Viral Purine and Pyrimidine Analogs.- Adenosine and Adenosine Receptors.- Purine Metabolism in Various Cells.- Nucleoside Transport.- Contributors.

Reihe/Serie	Advances in Experimental Medicine and Biology ; 253B
Zusatzinfo	XIII, 552 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-4684-5678-4 / 1468456784
ISBN-13	978-1-4684-5678-3 / 9781468456783
Zustand	Neuware