Total Synthesis of (±)-Maoecrystal V
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In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereo selective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.
Research Background for Natural Product Maoecrystal V and Its Family.- The Model Study of Natural Product Maoecrystal V.- The total synthesis study of Maoecrystal V.- Summary.
| Erscheint lt. Verlag | 10.3.2014 |
|---|---|
| Reihe/Serie | Springer Theses |
| Zusatzinfo | XII, 137 p. 177 illus., 1 illus. in color. |
| Verlagsort | Berlin |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 397 g |
| Themenwelt | Medizin / Pharmazie ► Pharmazie |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Naturwissenschaften ► Chemie ► Physikalische Chemie | |
| Schlagworte | Intramolecular Diels-Alder Reaction • Maoecrystal V • natural product • Pinhey Arylation • Stereoselective • Tetrahydrofuran Oxa-Bridge Skeleton • total synthesis • Wessely Oxidative Dearomatization |
| ISBN-13 | 9783642543036 / 9783642543036 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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