Pharmacogenomics (eBook)

Social, Ethical, and Clinical Dimensions

Mark A. Rothstein (Herausgeber)

eBook Download: PDF

2003 | 1. Auflage
368 Seiten
John Wiley & Sons (Verlag)
978-0-471-46120-3 (ISBN)

Infos

Through analyses of the complex underlying issues, this
interdisciplinary volume frames the agenda for dealing with genetic
variation and incorporating pharmacogenomics into health care. The
three sections of this book, Research Issues, Clinical Issues, and
Social Perspectives address key elements integral to a
comprehensive discussion of this emerging field.

This groundbreaking text...

* Examines new research strategies, methodologies, and ethical
and social considerations of pharmacogenomics

* Addresses practical considerations of anticipated changes in
education, training, oversight, guidelines and protocols, and
continuing education requirements

* Provides analyses of the potential enormous impact of
pharmacogenomics, such as in the standard of care and treatment,
including perspectives from the fields of anthropology, law,
ethics, and economics

Autor

Mark A. Rothstein holds the Herbert F. Boehl Chair of Law and Medicine and is Director of the Institute for Bioethics, Health Policy and Law at the University of Louisville. He has appointments in the Departments of Medicine and Family and Community Medicine at the School of Medicine and at the Louis D. Brandeis School of Law. Professor Rothstein is a leading authority on genetics, privacy, and health policy. He has served as an advisor to the NIH, CDC, DOE, Institute of Medicine, National Conference of State Legislatures, and numerous other public and professional entitles.

Inhalt

Foreword (F. Collins).

Preface.

PART I: INTRODUCTION: SCIENCE AND SOCIETY.

Public Attitudes About Pharmacogenomics (M. Rothstein, et
al.).

Pharmacogenomics: Pharmacology and Toxicology in the
Genomics (H. Mohrenweiser).

The Implications of Population Genetics for Pharmacogenomics (C.
Hanis).

PART II: RESEARCH AND DEVELOPMENT CHALLENGES AND
CONSIDERATIONS.

Genome Research and Minorities (H. Greely).

Drug Development Strategies (P. Manasco & T. Arledge).

Drug Development, Regulation, and Genetically Guided
Therapy Pharmacogenomics (D. Feigal & S. Gutman).

Intellectual Property and Commercial Aspects of Pharmacogenomics
(A. Nunnally, et al.).

PART III: CLINICAL APPLICATIONS.

Integration of Pharmacogenomics into Medical Practice (G. Omenn
& A. Motulsky).

Clinical Utility Pharmacogenetics and Pharmacogenomics (N.
Holtzman).

Medical Liability for Pharmacogenomics (L. Palmer).

The Challenges of Pharmacogenomics for Pharmacy Education,
Practice, and Regulation (D. Brushwood).

PART IV: THE SOCIAL DIMENSION.

Economic Implications of Pharmacogenomics (C. Reeder & W.
Dickson).

Pharmacogenomics and the Social Construction of Identity
(M. Foster).

Pharmacogenomics: Considerations for Communities of Color (L.
Nsiah-Jefferson).

Constitutional Issues in the Use of Pharmacogenomic Variations
Associated with Race (J. Robertson).

PART V: EPILOGUE: POLICY PRESCRIPTIONS (M. Rothstein).

Pharmacogenomics and Minority Populations: General Population
Survey Questionnaire (M. Rothstein).

Index.

Rezensionen

"The discussion of societal, legal, economic, and governmental
issues go well beyond the sphere of pharmogenomics." (American
Journal for Medical Genetics, September 1, 2005)

"...indispensable guide...as timely as it can be...an impressive
multidisciplinary analysis...a 'must read'..." (Bioethics,
Vol 18(4), August 2004)

"...Pharmacogenomics is highly recommended for anyone
with an interest in the field.... Given this book's
uniqueness...libraries at any institution teaching
pharmcogenomics should have a copy of this book." (Journal
of Pharmacy Technology, Sept/Oct 2003)

"...well written, clear, and informative...a restrained sense of
excitement...permeates throughout...clearly...a solid contribution
to the discourse." (Nature Biotechnology, May 1, 2003)

"...chapters offer fascinating glimpses into fields that may not
be familiar to geneticists, genomicists, or clinicians...they will
be informative...and provide a reminder that many people outside
this field are going to be paying a lot of attention as
discoveries...are reported." (New England Journal of
Medicine, July 24, 2003)

"...an excellent summary of aspects of phamacogenomics...a solid
reference for those working in the field and a unique textbook for
those new to the subject area." (Clinical Chemistry, Vol.
49, No. 9)

"...a welcome addition to the growing body of
literature...highly recommended for anyone with an interest in the
field...should be required reading for anyone conducting
pharmacogenomic research and for all clinicians who use
pharmacogenomics..." (Journal of Pharmacy Technology, Vol.
19September/October 2003)

"...addresses the ethical, legal, and social implications of the
individualized medicine that pharmacogenomics stands to create..."
(Genetic Engineering News, Vol 23(14), 2003)

"This volume presents the ethical, legal and social issues as they
interface with pharmacogenomics in a very readable and accessible
manner...this is an incredibly valuable guide by thought-leaders in
the field."

--Edward R. B. McCabe, M.D., Ph.D., David Geffen School of Medicine
at UCLA, Los Angeles, California

Produkt-Details

• Erscheint lt. Verlag: 9.4.2003
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Technik
• Schlagworte: Biotech & Gene Technology • Biotechnologie- u. Gentechnikrecht • Biowissenschaften • Ethik • Genetics • Genetik • Law • Life Sciences • Medical Science • Medizin • Pharmacology & Pharmaceutical Medicine • Pharmakologie • Pharmakologie u. Pharmazeutische Medizin • Rechtswissenschaft
• ISBN-10: 0-471-46120-2 / 0471461202
• ISBN-13: 978-0-471-46120-3 / 9780471461203