Signal Transduction and the Gasotransmitters

NO, CO, and H2S in Biology and Medicine

Rui Wang (Herausgeber)

Buch | Softcover

378 Seiten

2010 | Softcover reprint of hardcover 1st ed. 2004
Humana Press Inc. (Verlag)
978-1-61737-512-5 (ISBN)

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Distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels.

I. Gasotransmitters: Past, Present, and Future.- 1 The Evolution of Gasotransmitter Biology and Medicine: From Atmospheric Toxic Gases to Endogenous Gaseous Signaling Molecules.- 2 Interactions Between Gasotransmitters.- II. The Emergence of the First Gasotransmitter: Nitric Oxide.- 3 Nitric Oxide: Synthesis and Metabolism, Tissue Stores, and the Relationship of Endothelium-Derived Nitric Oxide to Endothelium-Dependent Hyperpolarization.- 4 Chemical Interaction of Nitric Oxide With Protein Thiols: S-Nitrosylation Signaling.- 5 Nitric Oxide and Adenosine Triphosphate-Sensitive Potassium Channels: Their Different Properties But Analogous Effects on Cellular Protection.- 6 Interactions of Nitric Oxide and Related Radical Species With KCa Channels.- 7 Nitric Oxide and Voltage-Gated Ca2+ Channels.- 8 Interactions of Nitric Oxide and Cardiac Ion Channels.- 9 S-Nitrosylation of Cyclic Nucleotide-Gated Channels.- III. Story of a Silent Killer: The Resurgence of Carbon Monoxide as the Second Gasotransmitter.- 10 Synthesis and Metabolism of Carbon Monoxide.- 11 Interaction of Carbon Monoxide With K+ Channels in Vascular Smooth Muscle Cells.- 12 Modulation of Multiple Types of Ion Channels by Carbon Monoxide in Nonvascular Tissues and Cells.- 13 The Molecular Mechanisms Underlying the Effects of Carbon Monoxide on Calcium-Activated K+ Channels.- 14 Carbon Monoxide and Signal Transduction Pathways.- 15 Carbon Monoxide-Induced Alterations in the Expression of KCa Channels in Pulmonary Artery Smooth Muscle Cells.- IV. Gas of the Rotten Egg: Hydrogen Sulfide as the Third Gasotransmitter.- 16 Hydrogen Sulfide Production and Metabolism in Mammalian Tissues.- 17 Toxicological and Environmental Impacts of Hydrogen Sulfide.- 18 Hydrogen Sulfide and the Regulation of Neuronal Activities.- 19 The Role of Hydrogen Sulfide as an Endogenous Vasorelaxant Factor.- 20 Hydrogen Sulfide and Visceral Smooth Muscle Contractility.- 21 Interaction of Hydrogen Sulfide and Adenosine Triphosphate-Sensitive Potassium Channels in Vascular Smooth Muscle Cells.- V. Gasotransmitters, Other Gaseous Molecules, and Cell Metabolism.- 22 Gasotransmitters as a Novel Class of Metabolic Regulators: Nitric Oxide, Carbon Monoxide, and Nitrous Oxide.

Erscheint lt. Verlag	5.11.2010
Zusatzinfo	XIV, 378 p.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-61737-512-8 / 1617375128
ISBN-13	978-1-61737-512-5 / 9781617375125
Zustand	Neuware