Progress in Medicinal Chemistry (eBook)

F.D. King, G. Lawton (Herausgeber)

eBook Download: PDF

2007 | 1. Auflage
232 Seiten
Elsevier Science (Verlag)
978-0-08-047131-0 (ISBN)

Infos

The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a 'quality lead', where these 'quality leads' come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry, relies upon defining those properties that historically have led to successful drug discovery. This volume addresses these questions and specifically discusses diabetes, obesity and tuberculosis.

*Presents the latest research in the field of drug discovery
*Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry
*Available as an online resource via ScienceDirect

Inhalt

Cover 1
Progress in Medicinal Chemistry 45 4
Copyright Page 5
Contents 8
Preface 6
List of Contributors 10
Chapter 1. Hit and Lead Identification: Efficient Practices for Drug Discovery 12
Introduction 12
Hit and Lead Identification Practices 13
Lead Identification as Reported for Specific Targets 22
Conclusion 60
References 61
Chapter 2. DPPIV Inhibition: Promising Therapy for the Treatment of Type 2 Diabetes 74
Introduction 75
Medicinal Chemistry and Preclinical Studies 82
Clinical Data for Oral DPPIV Inhibitors 107
Conclusions 112
Authors Note 113
References 113
Chapter 3. Recent Progress Toward Nonpeptide Ligands for the Melanocortin-4 Receptor 122
Introduction 123
Cyclohexylpiperidines as Potent MC4R Agonists 126
Cyclohexylpiperazines and Phenylpiperidines 137
Phenylpiperazines as MC4R Agonists 139
Other Classes of MC4R Agonists 144
Compounds Mimicking a-MSH and its Peptide Analogues 146
From Agonists to Antagonists 148
Small Molecule MC4R Antagonists from Initial Screen Hits 152
Other Nonpeptide MC4R Ligands 155
Interaction of the MC4R with Ligands 156
Medicinal Chemistry 166
Conclusion 169
References 170
Chapter 4. Tuberculosis Chemotherapy: Recent Developments and Future Perspectives 180
Introduction 181
TB Drug Development Pipeline 184
Potential New Drug Targets 198
Concluding Comments 205
Acknowledgments 206
References 207
Subject Index 216
Author Index (Vols. 1– 45) 220
Subject Index (Vols. 1– 45) 226

Produkt-Details

• Erscheint lt. Verlag: 13.4.2007
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Medizin / Pharmazie ► Pharmazie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Technik
• Themenwelt: Wirtschaft
• ISBN-10: 0-08-047131-5 / 0080471315
• ISBN-13: 978-0-08-047131-0 / 9780080471310