Annual Reports in Medicinal Chemistry (eBook)

eBook Download: PDF

1999 | 1. Auflage
413 Seiten
Elsevier Science (Verlag)
978-0-08-058378-5 (ISBN)

Infos

Annual Reports in Medicinal Chemistry continues to strive to provide timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences which are expected to provide the basis for entirely new future therapies.

Volume 34 retains the familiar format of previous volumes, this year with 33 chapters. Sections I-IV are disease-oriented and generally report on specific medicinal agents with updates from Volume 33 on antithrombotics, neurokinin receptor antagonists, anticoagualants, and new antibacterials. As in past volumes, annual updates have been limited to only the most active areas of research in favor of specifically focused and mechanistically oriented chapters, where the objective is to provide the reader with the most important new results in a particular field.

Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design as well as the critical interfaces among these disciplines. This volume concludes with To Market, To Market--a chapter on NCE and NBE introductions worldwide in 1998, a chapter on pharmagenomics, and finally one on malaria as a third world disease in need of a first world drug development.

Inhalt

Front Cover 1
Annual Reports in Medcinal Chemistry, Volume 34 4
Copyright Page 5
CONTENT 6
CONTRIBUTORS 10
PREFACE 12
SECTION I: CENTRAL NERVOUS SYSTEM DISEASES 14
Chapter 1. Recent Approaches to Novel Antidepressant Therapy 14
Chapter 2. Recent Progress in Corticotropin-Releasing Factor Receptor Agents 24
Chapter 3. ß-Amyloid as a Target for Alzheimer's Disease Therapy 34
Chapter 4. Recent Advances in the Development of Neuropeptide Y Receptor Antagonists 44
Chapter 5. Pharmacological Interventions in the Sleep Process 54
Chapter 6. Progress in the Development of Neurokinin Antagonists 64
SECTION II: CARDIOVASCULAR AND PULMONARY DISEASES 74
Chapter 7. Recent Approaches Towards Inhibiting Allergic Eosinophilia 74
Chapter 8. Pharmacological Therapy for the Treatment of Erectile Dysfunction 84
Chapter 9. Anticoagulants: Thrombin and Factor Xa Inhibitors 94
Chapter 10. Atherosclerosis: Emerging Pharmacological Approaches 114
Chapter 11. Current and Potential New Therapies for Chronic Obstructive 124
SECTION III: CANCER AND INFECTIOUS DISEASES 134
Chapter 12. The Urokinase-type Plasminogen Activator and Its Receptor in Cancer 134
Chapter 13. Progress in the Search for Anti-HCV Therapeutics 142
Chapter 14. Antimitotic Agents 152
Chapter 15. DNA Vaccines Coming of Age 162
Chapter 16. Development of Anti-Malarial Inhibitors of Hemoglobinases 172
Chapter 17. New Antibacterials for Resistant Organisms 182
SECTION IV: IMMUNOLOGY, ENDOCRINOLOGY AND METABOLIC DISEASES 192
Chapter 18. Inhibitors of lntegrin Alpha 4 Beta 1 (VLA-4) 192
Chapter 19. Glucagon and Glucagon-Like Peptide- 202
Chapter 20. Pharmacology of Cannabinoid Receptor Agonists and Antagonists 212
Chapter 21. Non-peptide Somatostatin Receptor Ligands 222
SECTION V: TOPICS IN BIOLOGY 232
Chapter 22. Cytokines in T Cell Maturation 232
Chapter 23. Genomics, Target Selection, Validation, and Assay Considerations 240
Chapter 24. The Case for Recombinant Production of Pharmaceutical Proteins in 250
Chapter 25. New Targets in Cell Cycle Regulation 260
Chapter 26. New Targets in Autoimmune Diseases 270
SECTION VI: TOPICS IN DRUG DESIGN AND DISCOVERY 280
Chapter 27. Application of Combinatorial and Parallel Synthesis to Medicinal 280
Chapter 28. Recent Developments in Molecular Diversity: Computational Approaches to Combinatorial Chemistry 300
Chapter 29. Structure-Based Drug Design 310
Chapter 30. Using Mass Spectrometry to Determine ADME Properties in Drug Discovery 320
SECTION VII: TRENDS AND PERSPECTIVES 330
Chapter 31. To Market, To Market - 1998 330
Chapter 32. Pharmacogenomics and its Impact on Drug Design and Optimisation 352
Chapter 33. Malaria: A Third World Disease in Need of First World Drug Development 362
COMPOUND NAME, CODE NUMBER AND SUBJECT INDEX, VOLUME 34 372
CUMULATIVE CHAPTER TITLES KEYWORD INDEX, VOLUMES 1-34 380
CUMULATIVE NCE INTRODUCTION INDEX, 1983-1998 396
CUMULATIVE NCE INTRODUCTION INDEX, 1983-1998, BY INDICATION 410

Produkt-Details

• Erscheint lt. Verlag: 8.9.1999
• Mitarbeit: Herausgeber (Serie): William Greenlee, William K. Hagmann, Jacob J. Plattner, David Robertson, George L. Trainor, Winnie W. Wong; Chef-Herausgeber: Annette M. Doherty
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie ► Analytische Chemie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Naturwissenschaften ► Chemie ► Physikalische Chemie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Themenwelt: Technik
• Themenwelt: Weitere Fachgebiete ► Land- / Forstwirtschaft / Fischerei
• ISBN-10: 0-08-058378-4 / 0080583784
• ISBN-13: 978-0-08-058378-5 / 9780080583785