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Therapeutic Proteins -

Therapeutic Proteins

Methods and Protocols
Buch | Hardcover
248 Seiten
2023 | 2024 ed.
Springer-Verlag New York Inc.
978-1-0716-3468-4 (ISBN)
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This volume covers the latest key aspects of therapeutic protein applications. Chapters in this book cover topics such as the discovery, production, and conjugation of protein-proteins with discussions on the direction of future development and advancements; ways to use these engineering proteins for therapeutic and vaccine applications; and the use of modified protein nanocarriers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and practical, Therapeutic Proteins: Methods and Protocols is a valuable resource for any researcher who are interested in learning more about the field of therapeutic proteins. 

lt;p>Preface...
Table of Contents...
Contributing Authors...

Part I Discovery, Production, and Conjugation of Therapeutic Proteins

1Optimizing Cell-Free Protein Synthesis for Antimicrobial Protein Production
Tejaswini Ramakrishna Hegde, Ogechi Okocha Rufus, Joongoo Lee, and Seok Hoon Hong

2Design and Construction of Antibody Fusion Proteins Incorporating Variable New Antigen Receptor (VNAR) Domains
Seth D. Ludwig, Angela Zhu, Ankith P. Maremanda, Helen M. Dooley, and Jamie B. Spangler

3Selective and Site-Specific Incorporation of Non-Standard Amino Acids within Proteins for Therapeutic Applications
Neil D. Butler and Aditya M. Kunjapur

4An Approach for Antigen-Agnostic Identification of Virus-Like Particle-Displayed Epitopes that Engage Specific Antibody V Gene Regions
Julianne Peabody, Susan Core, Larance Ronsard, Daniel Lingwood, David Peabody, and Bryce Chackerian

5Split-Protein Therapeutic Platforms: Identifying Binder Pairs
Christine S. Nervig, James R. Gustat, and Shawn C. Owen

6Metal-Mediated Ligand Affinity Chemistry (MLAC)  
Sailajah Gukathasan and Samuel G. Awuah

Part II Engineering Proteins for Therapeutic and Vaccine Applications

7Recombinant Elastin-Based Bioelastomers for Biomedical Applications
Paulina M. Babiak, Jason Minnich II, Jessica Torres, Sathvik Madduri, and Julie C. Liu

8Engineering Hepatitis B Virus (HBV) Protein Particles for Therapeutic Delivery
Millicent O. Sullivan and Wilfred Chen

9Design and Purification of Tag/Catcher AP205-Based Capsid Virus-Like Particle Vaccines
Kara-Lee Aves and Adam F. Sander

10Protein Nanocarriers Capable of Encapsulating Both Hydrophobic and Hydrophilic Drugs
Jooyong Shin, Blair D. Cole, Moosavizadeh Seyedmohammad, Sung In Lim, and Yeongseon Jang

11Unnatrual Amino Acid Engineering for Intracellular Delivery of Protein Therapeutics
Millicent O. Sullivan and Wilfred Chen

12Formulation of Chitosan-Zein Nano-in-Microparticles for Oral DNA Delivery
Kari Heck, Eric Farris, and Angela K. Pannier

13Engineering E2 Bionanoparticles for Targeted Delivery of Chemotherapeutics to Breast Cancer Cells
Millicent O. Sullivan and Wilfred Chen

14Constructing Nucleic Acid Delivering Lipoproteoplexes from Coiled-Coil Supercharged Protein and Cationic Liposomes
Joseph Thomas, Jonathan Sun, and Jin Kim Montclare

15Cancer Cell Silicification and Surface Functionalization to Create Microbial Mimetic Cancer Vaccines
Lorél Medina, Bryan Kaeh, and Rita E. Serda

16Melt-Processing Virus-Like Particle-Based Vaccine Candidates into Biodegradable Polymer Implants
Armando A. Puente, Oscar A. Ortega-Rivera, David M. Wirth, Jonathan K. Pokorski, and Nicole F. Steinmetz

Subject Index List...

Erscheinungsdatum
Reihe/Serie Methods in Molecular Biology
Zusatzinfo 47 Illustrations, color; 15 Illustrations, black and white; XI, 248 p. 62 illus., 47 illus. in color. With online files/update.
Verlagsort New York, NY
Sprache englisch
Maße 178 x 254 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Psychiatrie / Psychotherapie
Medizin / Pharmazie Physiotherapie / Ergotherapie Orthopädie
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Chemie
Technik Medizintechnik
Schlagworte Cell-free synthesis • Drug Delivery • Protein drug production • Protein Engineering • recombinant therapeutic proteins
ISBN-10 1-0716-3468-2 / 1071634682
ISBN-13 978-1-0716-3468-4 / 9781071634684
Zustand Neuware
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