Bugs as Drugs (eBook)
514 Seiten
John Wiley & Sons (Verlag)
978-1-55581-970-5 (ISBN)
Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease.
In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include:
* How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response.
* The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage.
* The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis.
* Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes.
Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted.
If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.
Robert A. Britton, Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France. Patrice D. Cani, Baylor College of Medicine, Molecular Virology and Microbiology, Houston, Texas.
Contributors vii
About the Editors xii
Preface xiii
A. Traditional Probiotic Approaches
1 Biochemical Features of Beneficial Microbes: Foundations for Therapeutic Microbiology 3
Melinda A. Engevik and James Versalovic
2 The Genomic Basis of Lactobacilli as Health-Promoting Organisms 49
Elisa Salvetti and Paul W. O'Toole
3 Bifidobacteria and Their Health-Promoting Effects 73
Claudio Hidalgo-Cantabrana, Susana Delgado, Lorena Ruiz, Patricia Ruas-Madiedo, Borja Sánchez, and Abelardo Margolles
B. Next-Generation Bacteriotherapy: Opportunities in Chronic Diseases
4 Microbial Interactions and Interventions in Colorectal Cancer 101
Terence Van Raay and Emma Allen-Vercoe
5 Microbial Impact on Host Metabolism: Opportunities for Novel Treatments of Nutritional Disorders? 131
Hubert Plovier and Patrice D. Cani
6 Therapeutic Opportunities in the Vaginal Microbiome 149
Gregor Reid
7 Lung Microbiota and Its Impact on the Mucosal Immune Phenotype 161
Benjamin G. Wu and Leopoldo N. Segal
8 Microbiota, Liver Diseases, and Alcohol 187
Anne-Marie Cassard, Philippe Gérard, and Gabriel Perlemuter
9 The Potential of Probiotics as a Therapy for Osteoporosis 213
Fraser L. Collins, Naiomy D. Rios-Arce, Jonathan D. Schepper, Narayanan Parameswaran, and Laura R. McCabe
10 Ecological Therapeutic Opportunities for Oral Diseases 235
Anilei Hoare, Philip D. Marsh, and Patricia I. Diaz
C. Control of Infectious Disease by Microbes
11 Control of Clostridium difficile Infection by Defined Microbial Communities 269
James Collins and Jennifer M. Auchtung
12 Fecal Microbiota Transplantation: Therapeutic Potential for a Multitude of Diseases beyond Clostridium difficile 291
Guido J. Bakker and Max Nieuwdorp
13 Enterococci and Their Interactions with the Intestinal Microbiome 309
Krista Dubin and Eric G. Pamer
D. Next-Generation Microbial Therapeutics: Tools and Regulation
14 Engineering Diagnostic and Therapeutic Gut Bacteria 333
Brian P. Landry and Jeffrey J. Tabor
15 Use of Traditional and Genetically Modified Probiotics in Human Health: What Does the Future Hold? 363
Luis G. Bermúdez-Humarán and Philippe Langella
16 Genetic Tools for the Enhancement of Probiotic Properties 371
Laura Ortiz-Velez and Robert Britton
17 Genome Editing of Food-Grade Lactobacilli to Develop Therapeutic Probiotics 389
Jan-Peter van Pijkeren and Rodolphe Barrangou
18 United States Regulatory Considerations for Development of Live Biotherapeutic Products as Drugs 409
Sheila M. Dreher-Resnick, Scott Stibitz, and Paul E. Carlson, Jr.
E. Indirect Strategies to Target Microbiome Function for Health
19 Bacteriophage Clinical Use as Antibacterial "Drugs": Utility and Precedent 419
Stephen T. Abedon
20 Modulation of the Gastrointestinal Microbiome with Nondigestible Fermentable Carbohydrates to Improve Human Health 453
Edward C. Deehan, Rebbeca M. Duar, Anissa M. Armet, Maria Elisa Perez-Muñoz, Mingliang Jin, and Jens Walter
Index 485
Because microbiome research studies are
being published at an unprecedented rate, a reliable book that reviews the
seminal work and knowledge gaps in this field is pressingly needed. In Bugs
as Drugs: Therapeutic Microbes for the Prevention and Treatment of Disease,
the authors address major themes in microbiome research, particularly focusing
on therapeutic applications.
This ~500-page volume, edited by Robert A.
Britton and Patrice D. Cani, comprises 5 main sections of varying scope and
length. The introductory section reviews pathways used by commensals,
particularly Lactobacilli and Bifidobacteria spp., to benefit the host. The
first chapter is particularly impressive, providing a thorough and well-cited
overview of the various microbial metabolites and how they influence the host.
...Overall, this book is a commendable and
timely volume of well-sourced reviews written by experts in the field well
organized into broad research themes. This work will serve as a helpful
resource for both scientists and clinicians interested in using microbes for
therapeutic applications.
-Excerpted from the full review in Emerging
Infectious Diseases, Vol. 25, No.7, Books and Media
Erscheint lt. Verlag | 2.7.2020 |
---|---|
Reihe/Serie | ASM | ASM |
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin |
Naturwissenschaften ► Biologie ► Biochemie | |
Technik ► Lebensmitteltechnologie | |
Schlagworte | Medical Science • Medizin • Microbiology • Mikroben • Mikrobiologie • Mikrobiologie u. Virologie • Mikroorganismus |
ISBN-10 | 1-55581-970-2 / 1555819702 |
ISBN-13 | 978-1-55581-970-5 / 9781555819705 |
Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
Haben Sie eine Frage zum Produkt? |
Größe: 13,5 MB
Kopierschutz: Adobe-DRM
Adobe-DRM ist ein Kopierschutz, der das eBook vor Mißbrauch schützen soll. Dabei wird das eBook bereits beim Download auf Ihre persönliche Adobe-ID autorisiert. Lesen können Sie das eBook dann nur auf den Geräten, welche ebenfalls auf Ihre Adobe-ID registriert sind.
Details zum Adobe-DRM
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen eine
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen eine
Geräteliste und zusätzliche Hinweise
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich