Modified Nucleic Acids

Kazuhiko Nakatani, Yitzhak Tor (Herausgeber)

Buch | Softcover

X, 276 Seiten

2018 | 1. Softcover reprint of the original 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-80076-9 (ISBN)

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This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.

Emissive 5-Substituted Uridine Analogues.- Fluorescent purine nucleosides and their applications.- Thiazole orange-tethered nucleic acids and ECHO probes for fluorometric detection of nucleic acids.- Synthetic wavelength-shifting fluorescent probes of nucleic acids.- DNA Assisted Multichromophore Assembly.- Polymerase Synthesis of Base-Modified DNA.- Photo-cross-linking Reaction in Nucleic Acids - Chemistry and Applications.- Site-Directed Spin Labeling for EPR Studies of Nucleic Acids.- Non-Covalent Modification of Double Stranded DNA at the Mismatch and Bulged Site.- 2',4'-Bridged Nucleic Acids for Targeting Double-Stranded DNA.- Specific Recognition of Single Nucleotide by Alkylating Oligonucleotides and Sensing of 8-oxoguanine.- Genetic alphabet expansion by unnatural base pair creation and its application to high affinity DNA aptamers.

Erscheinungsdatum	20.07.2018
Reihe/Serie	Nucleic Acids and Molecular Biology
Zusatzinfo	X, 276 p. 162 illus., 62 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	444 g
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Naturwissenschaften ► Chemie ► Organische Chemie
	Technik ► Maschinenbau
	Technik ► Umwelttechnik / Biotechnologie
Schlagworte	Base pair creation • biochemical engineering • Double-stranded DNA • Electron paramagnetic resonance (EPR) spectroscopy • Emission paramagnetic resonance spectroscopy • Nucleobases • Pyrimidine and purine analogs • Unnatural nucleic acids
ISBN-10	3-319-80076-0 / 3319800760
ISBN-13	978-3-319-80076-9 / 9783319800769
Zustand	Neuware