Drug Transporters (eBook)

Volume 1: Role and Importance in ADME and Drug Development

UK) Nicholls Glynis (Independent Consultant, Switzerland) Youdim Kuresh (F Hoffman-La Roche AG (Herausgeber)

eBook Download: PDF

2016
463 Seiten
Royal Society of Chemistry (Verlag)
978-1-78262-379-3 (ISBN)

Autor

Dr Glynis Nicholls has over 18 years experience within the pharmaceutical field in both academia and industry (including 7 years at GlaxoSmithKline and 5 years at AstraZeneca), specializing in drug transporter science from discovery through to clinical development. Dr Nicholls has played a leading role in writing and implementing internal transporter strategies within the industry, as well as collaborating across multiple international locations with internal and external colleagues on transporter-related projects and scientific developments, including PhD projects. Dr Kuresh Youdim has 9 years academic experience in the field of nutrition and neuroscience, plus 10 years pharmaceutical experience across multiple disciplines within drug discovery and development (including 8 years at Pfizer and 2 years at Roche) predominantly in the field of drug-drug interactions and PBPK modelling.

Inhalt

Overview of drug transporter families and their role in drug development; Liver transporters and their involvement in the hepatocellular uptake and export systems of organic anions; Intestinal transporters; Kidney transporters; CNS transporters; Lung transporters; The use of in vitro and in silico systems for investigating transporter interactions; The use of transgenic and knockout in vivo systems for investigating transporter interactions; Modelling and simulation of transporter interactions; Clinical Drug-Drug Interactions: An industrial Pharmaceutical Perspective; Regulatory requirements,  Labelling and Drug Transporters; Recent Advances and Emerging Technologies; Bioinformatics; Regulation of transporters; Transporter Pharmacogenomics; Transporter Imaging; Transporters and Proteomics

Produkt-Details

• Erscheint lt. Verlag: 16.8.2016
• Reihe/Serie: ISSN
• Reihe/Serie: ISSN
• Verlagsort: Cambridge
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Technik
• Schlagworte: 1 • ADME • Development • Drug • importance • Role • Transporters • Volume
• ISBN-10: 1-78262-379-5 / 1782623795
• ISBN-13: 978-1-78262-379-3 / 9781782623793