Collagen Mimetic Peptides and Their Biophysical Characterization

Jianxi Xiao (Autor)

Buch | Hardcover

226 Seiten

2024 | 2022 ed.
Springer Verlag, Singapore
978-981-10-1940-1 (ISBN)

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This book embarks on an enlightening journey through the molecular landscape of collagen mimic peptides, shedding light on their significance and potential. In the intricate realm of biomolecules, collagen's preeminence as the most abundant protein in the human body, forming the foundational scaffolding of tissues and organs, renders it a subject of profound scientific interest. It explores diverse facets related to collagen mimic peptides, spanning aspects such as bioinformatic analysis, synthetic strategies, pathological collagen targeting, and the construction of homotrimeric, heterotrimeric and self-assembled peptide models. Furthermore, it provides an exhaustive investigation into biophysical techniques, encompassing Circular Dichroism (CD), X-ray crystallography, Nuclear Magnetic Resonance (NMR), Fluorescence, and Raman spectroscopy, thereby empowering researchers to unravel the structural intricacies of these peptides. The book unravels the profound implications of collagen mimic peptides across a spectrum of scientific domains, including protein science, biomaterials, bioanalysis, and beyond. Its accessibility and insights cater not only to seasoned researchers but also to undergraduate and graduate students eager to delve into the complexities of this fundamental protein.

Dr. Jianxi Xiao received his bachelor's degree from Wuhan University in 2003 and completed his Ph.D. at Rutgers University-New Brunswick, New Jersey, in 2009. He pursued postdoctoral research at Rutgers University and subsequently attained a full professorship at Lanzhou University's College of Chemistry and Chemical Engineering in 2012. Dr. Xiao holds the distinguished title of Cuiying Scholar at Lanzhou University and is honored with the prestigious "Feitian Scholar" professorship in Gansu Province. In addition, he serves as Director of Medical Collagen Engineering Research Center in Gansu Province and as Director of Joint Collagen Research Center at Lanzhou University. His research interests encompass the development and characterization of innovative collagen mimic peptides, collagen-targeting peptide probes, and collagen-based biomaterials. Dr. Xiao's extensive work has significantly advanced our comprehension of collagen's structure, function, and pathology, leading to the publication of over 70 academic papers in esteemed journals.

Introduction to collagen.- Structure of collagen triple helix.- Bioinformatics-aided Design of collagen mimic peptides.- Synthesis of collagen peptides.- CD characterization of triple helix stability.- Structural insights from X-ray crystallography.- Conformational and dynamic characterization by NMR spectroscopy.- Fluorescence detection of collagen biomarkers.- Synthesis and characterization of heterotrimeric models of collagen.- Self-assembly of collagen mimic peptides.- Concluding remarks.

Erscheinungsdatum	28.04.2021
Reihe/Serie	Springer Series in Biomaterials Science and Engineering
Zusatzinfo	96 Illustrations, color; 12 Illustrations, black and white; XV, 226 p. 108 illus., 96 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Naturwissenschaften ► Chemie ► Analytische Chemie
	Naturwissenschaften ► Chemie ► Physikalische Chemie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
	Technik ► Maschinenbau
Schlagworte	Biomimetic peptide • Biophysics characterization • Circular dichroism spectrum • Collagen • NMR spectroscopy • Nuclear Magnetic Resonance • Protein dynamics • Protein Structure • Triple Helix • X-ray fluorescence
ISBN-10	981-10-1940-1 / 9811019401
ISBN-13	978-981-10-1940-1 / 9789811019401
Zustand	Neuware