Handbook for Chemical Process Research and Development

Wenyi Zhao (Autor)

Buch | Hardcover

810 Seiten

2016
Productivity Press (Verlag)
978-1-4987-6799-6 (ISBN)

Infos

The Handbook for Chemical Process Research and Development focuses on developing processes for chemical and pharmaceutical industries. Forty years ago there were few process research and development activities in the pharmaceutical industry, partially due to the simplicity of the drug molecules. However, with the increasing structural complexity, especially the introduction of chiral centers into the drug molecules and strict regulations set by the EMA and FDA, process R&D has become one of the critical departments for pharmaceutical companies. This book assists with the key responsibility of process chemists to develop chemical processes for manufacturing pharmaceutical intermediates and final drug substances for clinical studies and commercial production.

Autor

Dr. Wenyi Zhao, Senior Research Scientist (Process Chemistry), Member of the American Chemical Society. 1980–1990: Ph.D., Organic/Physical Organic Chemistry, Nanjing University, China. 1990–1992: Postdoctoral fellow at the Institute of Chemistry, Chinese Academy of Sciences, Beijing. 1992–1995: Associate Professor at the Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing (now the Institute of Chemistry, Chinese Academy of Sciences, Beijing). 1995–2001: Senior Research Associate in the Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas. Early in 2001, Dr. Zhao moved into the private sector to become a process chemist in the pharmaceutical industry in the United States. He is the author of numerous journal articles and holds several patents.

Inhalt

Chapter 1: Modes Of Reagent Addition – Control of Impurity Formation



Chapter 2: Process Optimization



Chapter 3: Hazardous Reactions



Chapter 4: Catalytic Reactions



Chapter 5: Grignard Reagent And Related Reactions



Chapter 6: Challenging Reaction Intermediates



Chapter 7: Protecting Groups



Chapter 8: Reaction Solvents



Chapter 9: Base Reagent Selection



Chapter 10: Reagents For Amide Formation



Chapter 11: Various Reagent Surrogates



Chapter 12: Telescope Approach



Chapter 13: Stereochemistry



Chapter 14: Design Of New Synthetic Route



Chapter 15: Reaction Workup



Chapter 16: Pharmaceutical Salts



Chapter 17: Solid Form

Produkt-Details

• Erscheinungsdatum: 11.12.2016
• Zusatzinfo: 20 Tables, black and white; 1446 Illustrations, black and white
• Verlagsort: Portland
• Sprache: englisch
• Maße: 178 x 254 mm
• Gewicht: 1655 g
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Naturwissenschaften ► Chemie ► Technische Chemie
• Themenwelt: Technik
• ISBN-10: 1-4987-6799-0 / 1498767990
• ISBN-13: 978-1-4987-6799-6 / 9781498767996
• Zustand: Neuware