Handbook for Chemical Process Research and Development

Wenyi Zhao (Autor)

Buch | Softcover

810 Seiten

2020
CRC Press (Verlag)
978-0-367-57441-3 (ISBN)

Infos

The Handbook for Chemical Process Research and Development focuses on developing processes for chemical and pharmaceutical industries. Forty years ago there were few process research and development activities in the pharmaceutical industry, partially due to the simplicity of the drug molecules. However, with the increasing structural complexity, especially the introduction of chiral centers into the drug molecules and strict regulations set by the EMA and FDA, process R&D has become one of the critical departments for pharmaceutical companies. This book assists with the key responsibility of process chemists to develop chemical processes for manufacturing pharmaceutical intermediates and final drug substances for clinical studies and commercial production.

Autor

Dr. Wenyi Zhao holds a PhD in Organic/Physical Chemistry from Nanjing University, China. After completing postdoctoral fellowships at the Chinese Academy of Sciences and Texas Tech University, he moved into the private sector to become a process chemist in the pharmaceutical industry in the US with over 15 years of experience. He is the author of numerous journal articles and holds several patents.

Inhalt

Chapter 1: Modes Of Reagent Addition – Control of Impurity Formation





Chapter 2: Process Optimization







Chapter 3: Hazardous Reactions







Chapter 4: Catalytic Reactions







Chapter 5: Grignard Reagent And Related Reactions







Chapter 6: Challenging Reaction Intermediates







Chapter 7: Protecting Groups







Chapter 8: Reaction Solvents







Chapter 9: Base Reagent Selection







Chapter 10: Reagents For Amide Formation







Chapter 11: Various Reagent Surrogates







Chapter 12: Telescope Approach







Chapter 13: Stereochemistry







Chapter 14: Design Of New Synthetic Route







Chapter 15: Reaction Workup







Chapter 16: Pharmaceutical Salts







Chapter 17: Solid Form

Produkt-Details

• Erscheinungsdatum: 01.07.2020
• Verlagsort: London
• Sprache: englisch
• Maße: 178 x 254 mm
• Gewicht: 1583 g
• Themenwelt: Naturwissenschaften ► Chemie ► Technische Chemie
• Themenwelt: Technik
• ISBN-10: 0-367-57441-1 / 0367574411
• ISBN-13: 978-0-367-57441-3 / 9780367574413
• Zustand: Neuware