Predictive ADMET (eBook)

Integrated Approaches in Drug Discovery and Development

Jianling Wang, Laszlo Urban (Autoren)

eBook Download: PDF

2014 | 1. Auflage
624 Seiten
John Wiley & Sons (Verlag)
978-1-118-78330-6 (ISBN)

Infos

This book helps readers integrate in silico, in
vitro, and in vivo ADMET (absorption,
distribution, metabolism, elimination and toxicity) and PK
(pharmacokinetics) data with routine testing applications so that
pharmaceutical scientists can diagnose ADMET problems and present
appropriate recommendations to move drug discovery programs
forward.

The book introduces the current clinical practice for drug
discovery and development along with the impact on early risk
assessment; consolidates the tools and models to intelligently
integrate existing in silico, in
vitro and in vivo ADMET data; and
demonstrates successful cases and lessons learned from real drug
discovery and development. In short, it is a book aimed to provide
a practical road map for drug discovery and development scientists
to generate efficacious and safe drugs for unmet medical needs.

Autor

Jianling Wang is the Cambridge Head of Discovery ADME at Novartis Institutes for BioMedical Research. He has published over 40 journal papers, reviews, and book chapters and lectured at over 30 scientific conferences and courses. Laszlo Urban is the Executive Director for Preclinical Safety Profiling at Novartis Institutes for BioMedical Research. He has over 10 years of experience in academia and 20 years in the pharmaceutical industry. Among Dr. Urban's publications are over 120 peer-reviewed scientific papers, 3 books including Hit and Lead Profiling: Identification and Optimization of Drug-like Molecules (Wiley, 2009).

Rezensionen

"In conclusion, this volume fulfills its promise of being a very useful tool for guidance and diagnosis on ADMET matters, and I would recommend it to any scientist in the field." (ChemMedChem, 1 June 2015)

Produkt-Details

• Erscheint lt. Verlag: 19.2.2014
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• Schlagworte: Analytical Chemistry • Analytische Chemie • Chemie • Chemistry • Drug Discovery & Development • Medical Science • Medizin • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung
• ISBN-10: 1-118-78330-1 / 1118783301
• ISBN-13: 978-1-118-78330-6 / 9781118783306