Phage Display In Biotechnology and Drug Discovery

Sachdev S. Sidhu, Clarence Ronald Geyer (Herausgeber)

Buch | Hardcover

584 Seiten

2015 | 2nd edition
Crc Press Inc (Verlag)
978-1-4398-3649-1 (ISBN)

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Phage Display in Biotechnology and Drug Discovery, Second Edition provides a comprehensive view of the impact and promise of phage display in drug discovery and biotechnology. Building on the success of its previous edition, the book discusses current theories, principles, and methods in the field and demonstrates applications for peptide phage display, protein phage display, and the development of novel antibodies.

The book provides readers with an overview of the amazing breadth of the impact that phage display technology has had on the study of proteins in general as well as the development of proteins. It will be a valuable resource for those interested in using phage display and recombinant antibodies in basic research and drug discovery.

Edited by Sachdev S. Sidhu, PhD, professor, Department of Molecular Genetics, University of Toronto, Ontario, Canada C. Ronald Geyer, PhD, professor, Department of Pathology, University of Saskatchewan, Canada

Filamentous Bacteriophage Structure and Biology. Vectors and Modes of Display. Methods for the Construction of Phage-Displayed Libraries. Selection and Screening Strategies. Leveraging Synthetic Phage-Antibody Libraries for Panning on the Mammalian Cell Surface. Phage Libraries for Developing Antibody-Targeted Diagnostics and Vaccines. Exploring Protein-Protein Interactions Using Peptide Libraries Displayed on Phage. Substrate Phage Display. Mapping Intracellular Protein Networks. High-Throughput and High-Content Screening Using Peptides. Engineering Protein Folding and Stability. Identification of Natural Protein-Protein Interactions with cDNA Libraries. Mapping Protein Functional Epitopes. Selections for Enzymatic Catalysts. Antibody Humanization and Affinity Maturation Using Phage Display. Antibody Libraries from Immunized Repertoires. Naive Antibody Libraries from Natural Repertoires. Synthetic Antibody Libraries. Engineering Antibody Fragments for Intracellular Applications.

Reihe/Serie	Drug Discovery Series
Zusatzinfo	150 Illustrations, black and white
Verlagsort	Bosa Roca
Sprache	englisch
Maße	156 x 234 mm
Gewicht	1240 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pflege
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Chemie
	Technik
ISBN-10	1-4398-3649-3 / 1439836493
ISBN-13	978-1-4398-3649-1 / 9781439836491
Zustand	Neuware