Phage Display In Biotechnology and Drug Discovery
CRC Press (Verlag)
978-1-138-89467-9 (ISBN)
The book provides readers with an overview of the amazing breadth of the impact that phage display technology has had on the study of proteins in general as well as the development of proteins. It will be a valuable resource for those interested in using phage display and recombinant antibodies in basic research and drug discovery.
Key Features:
Describes the basic principles of phage display and the methods and systems that have been developed for key applications
Outlines applications for peptide phage display in the development of vaccines and high- throughput screens as well as the exploration of protein–protein interactions and enzyme substrate characteristics
Details the use of phage display in the engineering of protein stability, the identification and mapping of protein–protein interactions, and the development of catalysts
Provides broad coverage of the impact of phage display technology on the development of protein therapeutics
Presents expert opinions on future challenges in the field
Edited by Sachdev S. Sidhu, PhD, professor, Department of Molecular Genetics, University of Toronto, Ontario, Canada C. Ronald Geyer, PhD, professor, Department of Pathology, University of Saskatchewan, Canada
Filamentous Bacteriophage Structure and Biology. Vectors and Modes of Display. Methods for the Construction of Phage-Displayed Libraries. Selection and Screening Strategies. Leveraging Synthetic Phage-Antibody Libraries for Panning on the Mammalian Cell Surface. Phage Libraries for Developing Antibody-Targeted Diagnostics and Vaccines. Exploring Protein-Protein Interactions Using Peptide Libraries Displayed on Phage. Substrate Phage Display. Mapping Intracellular Protein Networks. High-Throughput and High-Content Screening Using Peptides. Engineering Protein Folding and Stability. Identification of Natural Protein-Protein Interactions with cDNA Libraries. Mapping Protein Functional Epitopes. Selections for Enzymatic Catalysts. Antibody Humanization and Affinity Maturation Using Phage Display. Antibody Libraries from Immunized Repertoires. Naive Antibody Libraries from Natural Repertoires. Synthetic Antibody Libraries. Engineering Antibody Fragments for Intracellular Applications.
| Erscheinungsdatum | 25.07.2017 |
|---|---|
| Reihe/Serie | Drug Discovery Series |
| Verlagsort | London |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 453 g |
| Themenwelt | Medizin / Pharmazie ► Pflege |
| Medizin / Pharmazie ► Pharmazie ► PTA / PKA | |
| Naturwissenschaften ► Biologie | |
| Naturwissenschaften ► Chemie | |
| Technik | |
| ISBN-10 | 1-138-89467-2 / 1138894672 |
| ISBN-13 | 978-1-138-89467-9 / 9781138894679 |
| Zustand | Neuware |
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