Hepatitis C Virus: From Molecular Virology to Antiviral Therapy (eBook)

Ralf Bartenschlager (Herausgeber)

eBook Download: PDF

2013 | 2013
VIII, 346 Seiten
Springer Berlin (Verlag)
978-3-642-27340-7 (ISBN)

Infos

Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.

Inhalt

The Origin of Hepatitis C VirusPeter Simmonds Cell Culture Systems for Hepatitis C VirusEike Steinmann and Thomas Pietschmann Animal Models for Hepatitis CEva Billerbeck, Ype de Jong, Marcus Dorner, Cynthia de la Fuente, and Alexander Ploss Hepatitis C Virus EntryMirjam B. Zeisel, Daniel J. Felmlee, and Thomas F. Baumert Hepatitis C Virus Proteins: From Structure to FunctionDarius Moradpour and François Penin Hepatitis C Virus RNA Translation Michael Niepmann Hepatitis C Virus RNA ReplicationVolker Lohmann Virion Assembly and ReleaseBrett D. Lindenbach Innate Immune Responses to Hepatitis C VirusJohn W. Schoggins and Charles M. Rice Adaptive Immune Responses in Hepatitis C Virus InfectionChristoph Neumann-Haefelin and Robert Thimme Liver Injury and Disease Pathogenesis in Chronic Hepatitis CDaisuke Yamane, David R. McGivern, Takahiro Masaki, and Stanley M. Lemon Hepatitis C Virus-Specific Directly Acting Antiviral DrugsLeen Delang, Johan Neyts, Inge Vliegen, Sergio Abrignani, Petra Neddermann, and Raffaele De Francesco Treatment of Chronic Hepatitis C: Current and FutureJean-Michel Pawlotsky

Produkt-Details

• Erscheint lt. Verlag: 12.3.2013
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Zusatzinfo: VIII, 346 p. 34 illus., 20 illus. in color.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Technik
• Schlagworte: antibacterial drug resistance • Chronic liver disease • Disease pathogenesis • HCV entry • hepatology • immune response • RNA replication • RNA translation
• ISBN-10: 3-642-27340-8 / 3642273408
• ISBN-13: 978-3-642-27340-7 / 9783642273407