Genomics (eBook)

Applications in Human Biology

Sandy B. Primrose, Richard Twyman (Autoren)

eBook Download: PDF

2008 | 1. Auflage
232 Seiten
John Wiley & Sons (Verlag)
978-0-470-75127-5 (ISBN)

Infos

Written by the successful author team of Sandy Primrose and Richard
Twyman, Genomics: Applications in Human Biology is a topical
book showing how the new science of genomics is adding impetus to
the advances in human health provided by biotechnology.

* * Written to provide the necessary overview of the subject,
covering technological developments, applications and (where
necessary) the ethical implications.

* Divided into three sections, the first section introduces the
role of biotechnology and genomics in medicine and sets out some of
the technological advances that have been the basis of recent
medical breakthroughs.

* The second section takes a closer look at how biotechnology and
genomics are influencing the prevention and treatment of different
categories of disease.

* Finally the contribution of biotechnology and genomics to the
development of different types of therapy is described, including
conventional drugs, recombinant proteins and gene/cell
therapies.

* References to appropriate sections in other two popular books,
authored by Sandy Primrose and Richard Twyman, are included -
Principles of Gene Manipulation and Principles of Gene Analysis and
Genomics.

* Features several categories of boxed text, including history
boxes (describing the origins and development of particular
technologies or treatments), molecular boxes (featuring the
molecular basis of diseases or treatments in more detail) and ethic
boxes (which discusses the ethical implications of technology
development and new therapies).

Autor

Sandy Primrose was an academic for 10 years and a senior manager in the biotechnology industry for 20 years. He now manages a consultancy practice focused on technology management. He is also Visiting Professor at the Universities of Warwick and Liverpool, and sits on the board of a number of biotechnology companies. Richard Twyman worked as a research scientist at the University of Warwick and the MRC Laboratory of Molecular Biology in Cambridge before taking up scientific writing as a full-time occupation in 1998. He is currently a Visiting Fellow at the Department of Biology, University of York, and manages a company that provides scientific writing services.

Inhalt

Chapter One: Biotechnology And Genomics In Medicine.

Introduction.

Recombinant DNA Technology.

From Recombinant DNA To Molecular Medicine.

Gene Medicine.

Disease Models.

The Impact Of Genomics On Medicine.

The New Molecular Medicine.

Outline Of This Book.

Further Reading.

Chapter Two: An Overview Of Genomics.

Introduction.

A Review Of Progress: The Human Genome Project.

The Future: Functional Genomics.

Mutational Genomics.

Further Reading.

Chapter Three: Genomics And The Challenge Of Infectious
Disease.

Microorganisms Causing Disease.

Where Do New Diseases Come From?.

Identifying The Causative Agent Of A Disease.

Molecular Epidemiology.

Host Resistance To Infection.

Understanding Bacterial Pathogenicity.

Comparative Genomics And Genome Plasticity.

Combating Infectious Disease.

Further Reading.

Chapter Four: Analyzing And Treating Genetic
Diseases.

Genetic Disease In Context.

Detecting Single Gene Disorders.

Treating Single Gene Disorders.

Finding Genes For Monogenic Diseases And Determining Gene
Function.

Analysis Of Polygenic Disorders.

Haplotypes.

The Major Histocompatibility Complex (MHC).

Individual Responses To Drugs (Pharmacogenomics).

Further Reading.

Chapter Five: Diagnosis And Treatment Of Cancer.

Introduction.

The Impact Of Genomics On Cancer Research.

New Methods For The Diagnosis Of Cancer.

New Approaches To Cancer Therapy.

Further Reading.

Chapter Six: The Large Scale Production Of
Biopharmaceuticals.

Overview.

The Generation Of Monoclonal Antibodies.

The Large Scale Culture Of Microorganisms.

The Large Scale Culture Of Animal Cells.

Expression Systems.

Downstream Processing.

Using Gene Manipulation To Facilitate Downstream Processing. Of
Biopharmaceuticals.

The Quality Of Biopharmaceuticals.

Good Manufacturing Practice.

Alternative Production Systems.

Further Reading.

Chapter Seven: Genomics And The Development Of New Chemical
Entities.

Introduction. How Drugs Are Developed.

High-Throughput Screening.

Target Validation And Animal Models.

Combinatorial Chemistry.

Dynamic Combinatorial Libraries.

Virtual Screening.

Combinatorial Biosynthesis And Chemobiosynthesis.

Drug Metabolism.

Toxicogenomics.

Further Reading.

Chapter Eight: Gene And Cell Therapies.

Introduction.

Gene Therapy.

Nucleic Acids As Drugs.

DNA Vaccines.

Disease Models.

Cell Therapy.

Further Reading.

Produkt-Details

• Erscheint lt. Verlag: 8.5.2008
• Sprache: englisch
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Technik ► Umwelttechnik / Biotechnologie
• Schlagworte: Biotechnologie i. d. Biowissenschaften • Biotechnology • Biowissenschaften • Genomforschung u. Proteomik • Genomics & Proteomics • Life Sciences
• ISBN-10: 0-470-75127-4 / 0470751274
• ISBN-13: 978-0-470-75127-5 / 9780470751275