Preclinical Development Handbook (eBook)

ADME and Biopharmaceutical Properties

Shayne Cox Gad (Herausgeber)

eBook Download: PDF

2008 | 1. Auflage
1352 Seiten
John Wiley & Sons (Verlag)
978-0-470-24902-4 (ISBN)

Infos

A clear, straightforward resource to guide you through preclinical
drug development

Following this book's step-by-step guidance, you can successfully
initiate and complete critical phases of preclinical drug
development. The book serves as a basic, comprehensive reference to
prioritizing and optimizing leads, dose formulation, ADME,
pharmacokinetics, modeling, and regulations. This authoritative,
easy-to-use resource covers all the issues that need to be
considered and provides detailed instructions for current methods
and techniques.

Each chapter is written by one or more leading experts in the
field. These authors, representing the many disciplines involved in
preclinical toxicology screening and testing, give you the tools
needed to apply an effective multidisciplinary approach. The editor
has carefully reviewed all the chapters to ensure that each one is
thorough, accurate, and clear.

Among the key topics covered are:

* Modeling and informatics in drug design

* Bioanalytical chemistry

* Absorption of drugs after oral administration

* Transporter interactions in the ADME pathway of drugs

* Metabolism kinetics

* Mechanisms and consequences of drug-drug interactions

Each chapter offers a full exploration of problems that may be
encountered and their solutions. The authors also set forth the
limitations of various methods and techniques used in determining
the safety and efficacy of a drug during the preclinical
stage.

This publication should be readily accessible to all pharmaceutical
scientists involved in preclinical testing, enabling them to
perform and document preclinical safety tests to meet all FDA
requirements before clinical trials may begin.

Autor

SHAYNE COX GAD, PHD, DABT, ATS, is the Principal of Gad Consulting Services. Dr. Gad has more than thirty years of experience as a toxicologist, statistical consultant, manager, and general consultant on research and development in the chemical, consumer product, contract testing, biotechnology, medical device, and pharmaceutical industries. He is the author of thirty- four books and numerous papers, presentations, and other publications.

Rezensionen

"A valuable source of reference and one that I'm sure will get regular use. The diversity of topics should appeal to a variety of pharmaceutical scientists." (The British Toxicology Newsletter, Winter 2008)

Produkt-Details

• Erscheint lt. Verlag: 2.7.2008
• Reihe/Serie: Pharmaceutical Development
• Reihe/Serie: Pharmaceutical Development
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• Schlagworte: Chemie • Chemistry • Drug Discovery & Development • Medical Science • Medizin • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Pharmazeutische Medizin • Toxicology • Toxikologie • Wirkstoffforschung u. -entwicklung
• ISBN-10: 0-470-24902-1 / 0470249021
• ISBN-13: 978-0-470-24902-4 / 9780470249024