Dendrimer-Based Drug Delivery Systems (eBook)

From Theory to Practice

Yiyun Cheng (Herausgeber)

eBook Download: PDF

2012 | 1. Auflage
534 Seiten
John Wiley & Sons (Verlag)
978-1-118-27520-7 (ISBN)

Infos

The opportunities and challenges of using dendrimers to improve
drug delivery

Among pharmaceutical and biomedical researchers, the use of
dendrimers in drug delivery systems has attracted increasing
interest. In particular, researchers have noted that the volume of
a dendrimer increases when it has a positive charge. If this
property can be applied effectively, dendrimers have enormous
potential in drug delivery systems, directly supplying medication
to targeted human organs.

With contributions from an international team of pioneers and
experts in dendrimer research, this book provides a comprehensive
overview of the latest research efforts in designing and optimizing
dendrimer-based drug delivery systems. The book analyzes key
issues, demonstrating the critical connections that link
fundamental concepts, design, synthesis, analytical methodology,
and biological assessment to the practical use of dendrimers in
drug delivery applications. Topics covered include:

* Dendrimer history

* Synthesis

* Physicochemical properties

* Principles of drug delivery

* Applications in diverse biomedical fields

Dendrimer-Based Drug Delivery Systems reflects the
authors' thorough review and analysis of the current literature as
well as their own firsthand experience in the lab. Readers will not
only discover the current state of the science, but also gain
valuable insights into fruitful directions for future research.
References at the end of each chapter serve as a gateway to the
growing body of literature in the field, enabling readers to
explore each individual topic in greater depth.

Pharmaceutical and biomedical researchers will find this book a
unique and essential guide to the opportunities, issues, and
challenges involved in fully exploiting the potential of dendrimers
to improve drug delivery.

Autor

YIYUN CHENG, PhD, is a Full Professor of Biomedical Engineering at the School of Life Science of East China Normal University. His research interests focus on the biomedical applications of dendrimers and other dendritic polymers. Dr. Cheng has published more than forty peer-reviewed manuscripts in such journals as Nature Materials, Chemical Society Reviews, and Journal of the American Chemical Society.

Inhalt

Foreword vii

Donald A. Tomalia

Preface ix

Acknowledgments xi

Contributors xiii

About the Editor xvii

1 Dendrimer Chemistry: Supramolecular Perspectives and
Applications 1

Charles N. Moorefield, Sujith Perera, and George R.
Newkome

2 Physicochemical Properties of Dendrimers and Dendrimer
Complexes 55

Toyoko Imae

3 The Use of Dendrimers to Optimize the Physicochemical and
Therapeutic Properties of Drugs 93

Nicole Stieger, Wilna Liebenberg, Marique E. Aucamp, and
Melgardt M. de Villiers

4 Biological Properties of Phosphorus Dendrimers 139

Anne-Marie Caminade and Jean-Pierre Majoral

5 Dendrimer-Based Prodrugs: Synthesis and Biological Evaluation
157

Mohammad Najlah, Zhengyuan Zhou, and Antony
D'Emanuele

6 Improving the Biocompatibility of Dendrimers in Drug Delivery
207

Yiwen Li, Libo Zhao, and Yiyun Cheng

7 Degradable Dendrimers for Drug Delivery 239

Marc Gingras and Myriam Roy

8 Design of Stimuli-Responsive Dendrimers for Biomedical
Purposes 307

Chie Kojima

9 Dendrimer-Based Gene Delivery Systems: Administration Routes
and In Vivo Evaluation 329

Santander-Ortega M.J., Uchegbu I.F., and Scha¨tzlein
A.G.

10 Triazine Dendrimers for DNA and siRNA Delivery: Progress,
Challenges, and Opportunities 355

Meredith A. Mintzer, Olivia M. Merkel, Thomas Kissel, and Eric
E. Simanek

11 Dendrimer-Coated Carbohydrate Residues as Drug Delivery
Trojan Horses in Glycoscience 407

Yoann M. Chabre and Rene´ Roy

12 Nuclear Magnetic Resonance Techniques in the Analysis of
Pamam Dendrimer-Based Drug Delivery Systems 439

Xueyan Feng, Kun Yang, Jingjing Hu, Tongwen Xu, and Yiyun
Cheng

13 Dendrimer-Based Medical Nanodevices for Magnetic Resonance
Imaging Applications 463

Hongdong Cai, Mingwu Shen, and Xiangyang Shi

14 Dendrimer-Related Nanoparticle System for Computed Tomography
Imaging 479

Chen Peng and Xiangyang Shi

Index 501

Rezensionen

"This book should be particularly valuable for everyone
working in the dendrimer area, but also for researchers in drug
delivery and pharmaceutical sciences more generally. To my mind, it
is clearly a book to have on your shelf!."
(ChemMedChem, 1 March 2013)

Produkt-Details

• Erscheint lt. Verlag: 6.5.2012
• Reihe/Serie: Wiley series in drug discovery and development
• Reihe/Serie: Wiley series in drug discovery and development
• Vorwort: Donald A. Tomalia
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik ► Umwelttechnik / Biotechnologie
• Schlagworte: Biomaterial • Biomaterialien • biomaterials • biomedical engineering • Biomedizintechnik • Chemie • Chemistry • Dendrimere • Medical Science • Medizin • Pharmaceutical & Medicinal Chemistry • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Pharmazeutische Chemie • Pharmazeutische u. Medizinische Chemie
• ISBN-10: 1-118-27520-9 / 1118275209
• ISBN-13: 978-1-118-27520-7 / 9781118275207