Drug Efficacy, Safety, and Biologics Discovery (eBook)

Emerging Technologies and Tools

Sean Ekins, Jinghai J. Xu (Herausgeber)

eBook Download: PDF

2009 | 1. Auflage
400 Seiten
Wiley (Verlag)
978-0-470-43180-1 (ISBN)

Infos

Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.

Autor

Sean Ekins, MSc, PHD, DSc, is the Principal at Collaborations in Chemistry; and Adjunct Associate Professor in the Department of Pharmaceutical Sciences at the University of Maryland, School of Pharmacy. Dr. Ekins has published widely on ADME/Tox, systems biology, computational, and in vitro drug discovery approaches. He has previously edited two Wiley books: Computer Applications in Pharmaceutical Research and Development (2006) and Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals (2007). Jinghai J. Xu, PHD, is Director of Automated Biotechnology at Merck. Previously he headed predictive toxicology at Pfizer, where he led research activities in drug-induced liver injury, genetic toxicology, drug transporters, assay development, high content screening, in vitro in vivo correlations, systems biology, and systems toxicology. Dr. Xu has served on steering committees of academic-industry and industry-industry collaborations, and as a guest lecturer at the Massachusetts Institute of Technology.

Inhalt

Preface.

Acknowledgments.

Contributors.

PART I: DRUG EFFICACY AND SAFETY TECHNOLOGY.

1. Focus on Fundamentals: Towards Better Therapeutic Index
Prediction (Jinghai J. Xu and Li J. Yu).

2. High-Throughput Protein-Based Technologies and Computational
Models for Drug Development, Efficacy and Toxicity (Leonidas G.
Alexopoulos, Julio Saez-Rodriguez and Christopher W. Espelin).

3. Cellular Systems Biology Applied to Pre-Clinical Safety
Testing: A Case Study of CellCiphr¯TM
Profiling (Lawrence Vernetti, William Irwin, Kenneth A. Giuliano,
Albert Gough, Kate Johnston and D. Lansing Taylor).

4. Systems Pharmacology, Biomarkers and Biomolecular Networks
(Aram Adourian, Thomas N. Plasterer, Raji Balasubramanian, Ezra
Jennings, Shunguang Wang, Jan van der Greef, Robert McBurney,
Pieter Muntendam, and Noubar Afeyan).

5. Zebrafish Models for Human Diseases and Drug Discovery
(Hanbing Zhong, Ning-Ai Liu and Shuo Lin).

6. Toxicity Pathways and Models: Mining for Potential Side
Effects (Sean Ekins and Josef Scheiber).

7. Computational Systems Biology Modeling of Dosimetry and
Cellular Response Pathways (Qiang Zhang, Yu-Mei Tan, Sudin
Bhattacharya and Melvin E. Andersen).

8. Stem Cell Technology for Embryotoxicity, Cardiotoxicity and
Hepatotoxicity Evaluation (Julio C. Davila, Donald B. Stedman,
Sandra J. Engle, Howard I. Pryor II and Joseph P. Vacanti).

9. Telemetry Technology for Preclinical Drug Discovery and
Development (Yi Yang).

PART II. BIOLOGICS TECHNOLOGY.

10. Nanotechnology to Improve Oral Drug Delivery (Mayank D.
Bhavsar, Shardool Jain, and Mansoor M. Amiji).

11. Functional Glycomics and the Future of Glycomic Drugs (Ram
Sasisekharan).

12. Modeling Efficacy and Safety of Engineered Biologics (Jeff
Chabot and Bruce Gomes).

13. Regulation of Gene Expression by Small, Non-Coding RNAs:
Practical Applications (Roman Herrara and Eric Tien).

PART III. FUTURE PERSPECTIVE.

14. Future Perspectives of Biological Engineering in
Pharmaceutical Research: The Paradigm of Modeling, Mining,
Manipulation and Measurements (Jinghai J. Xu, Sean Ekins, Michael
McGlashen and Douglas Lauffenburger).

Index.

Produkt-Details

• Erscheint lt. Verlag: 26.3.2009
• Reihe/Serie: Wiley Series on Technologies for the Pharmaceutical
• Reihe/Serie: Wiley Series on Technologies for the Pharmaceutical
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• Schlagworte: Arzneimittelentwicklung • Biowissenschaften • Cell & Molecular Biology • Chemie • Chemistry • Drug Discovery & Development • Life Sciences • Medical Science • Medizin • Molekularbiologie • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung • Zell- u. Molekularbiologie
• ISBN-10: 0-470-43180-6 / 0470431806
• ISBN-13: 978-0-470-43180-1 / 9780470431801