Allosteric Regulatory Enzymes (eBook)

Thomas W. Traut (Autor)

eBook Download: PDF

2007 | 2008
XIV, 250 Seiten
Springer US (Verlag)
978-0-387-72891-9 (ISBN)

Infos

This book covers the most recent developments in the analysis of allosteric enzymes and provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. The book presents a complete description of all the mechanisms used for changing enzyme activity. It is extensively illustrated to clarify kinetic and regulatory properties. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.

Thomas Traut has a PhD in molecular biology and has studied enzymes since 1974.  As a professor at the University of North Carolina at Chapel Hill, he has focused on enzyme regulation and taught advanced enzymology to graduate students.  Important findings from his research helped to define the mechanism of allosteric control for dissociating enzymes. 

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All enzymes are remarkable since they have the ability to increase the rate of a chemical reaction, often by more than a billion-fold. Allosteric enzymes are even more amazing because the have the additional ability to change their rate in response to cellular activators or inhibitors. This enables them to control the pathway in which they are the regulatory enzyme. Since the effector molecules represent the current status of the cell for a given metabolic pathway, this results in very responsive and balanced metabolic states, and makes it possible for cells and organisms to be appropriately dynamic, and responsive, in a changing environment. This book provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. This book presents a complete description of all the mechanisms used for changing enzyme acticity. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.

Inhalt

CONTENTS 7
OVERVIEW OF ENZYMES 14
INTRODUCTION TO ENZYMES 15
THE LIMITS FOR LIFE DEFINE THE LIMITS FOR ENZYMES 41
ENZYME KINETICS 61
PROPERTIES AND EVOLUTION OF ALLOSTERIC ENZYMES 75
KINETICS OF ALLOSTERIC ENZYMES 88
K-TYPE ENZYMES 114
HEMOGLOBIN 115
GLYCOGEN PHOSPHORYLASE 136
PHOSPHOFRUCTOKINASE 148
RIBONUCLEOTIDE REDUCTASE 169
HEXOKINASE 187
V-TYPE ENZYMES 207
V-TYPE ENZYMES 208
G PROTEINS 215
PROTEIN KINASES 221
REFERENCES 233
INDEX 246

Produkt-Details

• Erscheint lt. Verlag: 11.9.2007
• Zusatzinfo: XIV, 250 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik ► Bauwesen
• Themenwelt: Technik ► Medizintechnik
• Schlagworte: Aspartat • DNA • enzymes • Glycogen • Metabolism • Nucleotide • RNA • transcription
• ISBN-10: 0-387-72891-0 / 0387728910
• ISBN-13: 978-0-387-72891-9 / 9780387728919