Actin-Binding Proteins and Disease (eBook)

Cris dos Remedios, Deepak Chhabra (Herausgeber)

eBook Download: PDF

2008 | 2008
XIV, 348 Seiten
Springer New York (Verlag)
978-0-387-71749-4 (ISBN)

Infos

There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders. The volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole.

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Actin is a ubiquitous protein present in high concentrations in virtually all cells. It's assembly and disassembly is modulated by more than 100 actin-binding proteins. These interactions are essential for a variety of important cellular processes including cell division, gene expression and motility.There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders.This volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole. Additionally, clinicians will be interested because the book explains the role of cytoskeletal proteins in various diseases, including cancer and immune system disorders.

Inhalt

Actin.- Actin: An Overview of Its Structure and Function.- Actin Genetic Diseases.- Actin-Binding Drugs: An Elegant Tool to Dissect Subcellular Processes in Endothelial and Cancer Cells.- Autoantigenicity of Actin.- Actin-Binding Proteins.- Overview: Actin-Binding Protein Function and Its Relation to Disease Pathology.- ADF/Cofilin, Actin Dynamics, and Disease.- Gelsolin and Disease.- Profilin.- The Roles of Thymosin ?4 in Cell Migration and Cell-to-Cell Signaling in Disease.- Actin-Binding Proteins.- Actin and Actin-Binding Proteins in Cancer Progression and Metastasis.- Diseases with Abnormal Actin and Actin-Binding Proteins in Leukocyte and Nonmuscle Cells.- The Role of PIP2 in Actin, Actin-Binding Proteins and Disease.- Intracellular Pathogens and the Actin Cytoskeleton.- Actin and Its Binding Proteins in Heart Failure.

Produkt-Details

• Erscheint lt. Verlag: 8.1.2008
• Reihe/Serie: Protein Reviews
• Reihe/Serie: Protein Reviews
• Zusatzinfo: XIV, 348 p. 52 illus., 22 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Technik
• Schlagworte: cell division • cellular processes • gene expression • immune system • intracellular pathogens • Leukocytes • Migration • proteins • Proteomics
• ISBN-10: 0-387-71749-8 / 0387717498
• ISBN-13: 978-0-387-71749-4 / 9780387717494