Molecular Mechanisms of Exocytosis (eBook)

Romano Regazzi (Herausgeber)

eBook Download: PDF

2008 | 2007
IX, 178 Seiten
Springer New York (Verlag)
978-0-387-39961-4 (ISBN)

Infos

This book examines the role of key components in the exocytotic process, not only in neuronal and endocrine cells but in a variety of other relevant cell systems. So far, because of the large number of components involved, understanding of the molecular basis of exocytosis has remained the privilege of a relatively small group of specialists. The book collects up-to-date reviews from the forefront of this fascinating and rapidly evolving field.

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Exocytosis is a fundamental cellular process that is used by eukaryotic cells to release a variety of biological compounds including peptide hormones and neurotransmitters or to insert specific lipids and proteins in the plasma membrane. In recent years, a multidisciplinary approach promoted an extraordinary progress in the understanding of the molecular mechanisms regulating exocytosis. This led to the discovery of a large number of components belonging to the machinery that governs the fusion of secretory vesicles with plasma membranes in different cell systems, including neuronal and endocrine cells. The basic machinery required for vesicle fusion turned out to be well conserved through evolution from yeast to man. So far, because of the large number of components involved, understanding of the molecular basis of exocytosis has remained the privilege of a relatively small group of specialists. This book, written by recognized experts in the field aims at clarifying for a non-specialist audience the role of the key players in the exocytotic process not only in neuronal and endocrine cells but also in a variety of other relevant cell systems. The book represents a unique collection of up-to-date reviews that will introduce researchers and students to the forefront of this rapidly moving and fascinating field.

Inhalt

CONTENTS 4
PREFACE 7
EDITOR 8
CONTRIBUTORS 8
Exocytosis: Lessons from SNARE Mutants and Friends 10
Regulation of SNARE Complex Assembly by Second Messengers: Roles of Phospholipases, Munc 13 and Munc 18 19
Rab GTPases and Their Role in the Control of Exocytosis 37
The Role of Synaptotagmin and Synaptotagmin-Like Protein (Slp) in Regulated Exocytosis 51
The Synapsins and the Control of Neuroexocytosis 71
Phospholipase D: A Multi-Regulated Lipid-Modifying Enzyme Involved in the Late Stages of Exocytosis 84
Lipid Rafts as Regulators of SNARE Activity and Exocytosis 93
Mast Cells as a Model of Nonneuroendocrine Exocytosis 109
Acrosomal Exocytosis 126
Nonsecretory, Regulated Exocytosis: A Multifarious Mechanism Employed by Cells to Carry Out a Variety of Functions 157
Adaptation of the Secretory Machinery to Pathophysiological Gonditions 170
Index 183

Produkt-Details

• Erscheint lt. Verlag: 12.5.2008
• Reihe/Serie: Molecular Biology Intelligence Unit
• Reihe/Serie: Molecular Biology Intelligence Unit
• Zusatzinfo: IX, 178 p. 46 illus., 4 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• Schlagworte: Cell • Enzyme • enzymes • Evolution • Membrane • Molecular mechanisms • Neurotransmitter • Protein • proteins • Regulation
• ISBN-10: 0-387-39961-5 / 0387399615
• ISBN-13: 978-0-387-39961-4 / 9780387399614