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Glycoscience and Microbial Adhesion

Thisbe K. Lindhorst, Stefan Oscarson (Herausgeber)

Buch | Hardcover

XI, 186 Seiten

2009 | 2009
Springer Berlin (Verlag)
978-3-642-01303-4 (ISBN)

Lese- und Medienproben

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bacterial carbohydrate recognition are conveyed, covering Gram-positive as well as Gram-negative bacteria, in Chapter 4 Streptococci and Staphylococci, and in Chapter 5, carbohydrate binding specificities of Helicobacter pylori. In Chapter 6, Bitter sweetness of complexity, the collected reflections on mic- bial adhesion are expanded by a perspective on a broader impact of glycosylation on cellular adhesion, motility and regulatory processes, paralleling the complexity of N-glycan structures on cell surfaces. It highlights particularly how structural details of N-glycans have been causally related to pathological scenarios, with a focus on ?(1,6)-N-acetylglucosaminyltransferase. In the final chapter, biofilm formation is reviewed, covering knowledge about structure and biosynthesis of polysaccharide intercellular adhesins (PIAs) which are central to biofilm formation. This comprehensive chapter explains all PIA-related principles of medical device-associated infections. It is our hope, that this collection of expert articles, ranging from structural ch- istry and structural biology to biochemistry and medicine, will be a stimulation and motivation for our colleagues in the life sciences. At the same time, we hope that these reflections on microbial adhesion will awake interest in and promote und- standing of the complex processes associated with the glycocalyx and the multif- eted interactions between the host cell and its guest, as well as the biological consequences resulting from this mutual interplay.

Bitter Sweetness of Complexity.- Carbohydrate Receptors of Bacterial Adhesins: Implications and Reflections.- Structure, Function, and Assembly of Type 1 Fimbriae.- The Multiple Carbohydrate Binding Specificities of Helicobacter pylori.- Ins and Outs of Microbial Adhesion.- Staphylococcus epidermidis Biofilms: Functional Molecules, Relation to Virulence, and Vaccine Potential.- Architectures of Multivalent Glycomimetics for Probing Carbohydrate-Lectin Interactions.

Erscheint lt. Verlag	26.6.2009
Reihe/Serie	Topics in Current Chemistry
Zusatzinfo	XI, 186 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	504 g
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Chemie ► Organische Chemie
	Technik ► Umwelttechnik / Biotechnologie
Schlagworte	applied microbiology • biochemistry • Biofilm • carbohydrate chemistry • Chemistry • Glycomimetics • glycoscience • Microbial Adhesion • Polysaccharid • Polysaccharide
ISBN-10	3-642-01303-1 / 3642013031
ISBN-13	978-3-642-01303-4 / 9783642013034
Zustand	Neuware