Immunodermatology (eBook)

D. M. Macdonald (Herausgeber)

eBook Download: PDF | EPUB

2014 | 1. Auflage
312 Seiten
Elsevier Science (Verlag)
978-1-4831-9200-0 (ISBN)

Infos

Immunodermatology presents a comprehensive examination of the proceedings that resulted from the International Immunodermatology Symposium which happened in London. It discusses the relationship of immuno-histochemical study to skin disease. It addresses the function and recognition of lymphocytes. Some of the topics covered in the book are the immunological observations in 12 cases of Kaposi's herpetic eruption; anti-inflammatory effects of adrenoceptor agonists in patients with atopic eczema; a study of the sensitivity and specificity of cutaneous vascular immunofluorescence; and functional activity of granulocytes from patients with neutrophilic dermatoses. The mechanisms of cutaneous lupus erythematosus are fully covered. An in-depth account of the cytochemical and immunological findings in cutaneous multilobated cell lymphoma are provided. The immunohistological analysis of dermal leprous granulomas is completely presented. A chapter is devoted to the study of human epidermal cell differentiation using monoclonal antibodies. Another section focuses on the prognostic significance of melanoma-associated antigens in primary and metastatic melanomas. The book can provide useful information to doctors, dermatologists, students, and researchers.

Inhalt

Front Cover 1
Immunodermatology 4
Copyright Page 5
Table of Contents 16
Preface 6
Contributors 8
Part I: Eczema 22
Chapter 1. Kaposi's herpetic eruption: immunological 
24 
Introduction 24
Materials and methods 24
Results 24
Comment 24
References 25
Chapter 2. Anti-inflammatory effects of adrenoceptor 
26 
Introduction 26
Subjects and methods 26
Results 27
Discussion 27
References 28
Chapter 3. Specific hyposensitization and non-specific 
30 
Hyposensitization 30
Non-specific immunotherapy 31
Transfer factor 31
Comments 33
References 33
Chapter 4. Inhalant and food allergens in atopic eczema 
34 
Patients 34
Materials and methods 34
Results 34
Discussion 36
References 36
Chapter 5. Analysis of the IgE response to pure cows' milk 
38 
Introduction 38
Subjects studied 38
Materials and methods 38
Results 38
Discussion 41
References 41
Chapter 6. Abnormal intestinal permeability to lactulose in patients with atopic dermatitis 42
Introduction 42
Patients and methods 42
Results 42
Discussion 43
References 43
Chapter 7. Comparison of predictive drug photosensitivity models in guinea pigs, mice 
44 
General review 44
Induction techniques in guinea pigs 44
Induction techniques in mice 45
Induction techniques in humans 45
References 46
Chapter 8. Actinie reticuloid: sensitivity to light and fragrances 48
Case report 48
References 48
Chapter 
50 
Introduction 50
Methods 50
Results 51
Discussion 52
Acknowledgements 52
References 52
Chapter 10. Inhibition of the suppressor cell circuit of contact allergy by interferon 54
Methods 54
Results 54
Discussion 55
References 56
Chapter 11. Lymphocyte transformation test in allergie contact dermatitis by mercury 58
Materials and methods 58
Results 58
Discussion 59
References 60
Part II: Labelled antibody studies 62
Chapter 12. Quantitative analysis of HLA-DR antigen expression by normal human 
64 
Introduction 64
Materials and methods 64
Results 65
Discussion 67
References 67
Chapter 13. Studies of human epidermal cell differentiation 
68 
Introduction 68
Materials and methods 68
Results 69
Discussion 72
References 73
Chapter 14. Epidermal B2M labelling in verrucous carcinoma, viral warts and pseudoepitheliomatous 
74 
Introduction 74
Materials and methods 74
Antisera 74
Results 74
Discussion 75
References 75
Chapter 15. Epithelial markers in primary skin cancer. An immunoperoxidase study 76
Introduction 76
Methods 76
Controls 76
Results 76
Discussion 79
Acknowledgements 79
References 80
Chapter 16. Carcinoembryonic antigen in mammary and extramammary Paget's disease 82
Introduction 82
Patients and methods 82
Results 83
Discussion 84
References 85
Chapter 17. S-100 protein: an immunohistochemical study of fetal eccrine 
86 
Materials and methods 86
Results 88
Discussion 88
References 91
Chapter 18. Prognostic significance of melanoma-associated antigens in primary and metastatic melanomas 92
Results and discussion 92
Acknowledgements 95
References 95
Chapter 19. 
96 
Materials and methods 96
Results 96
Discussion 97
References 98
Chapter 20. Immunohistochemical localization of factor VIII related antigen in Kaposi's sarcoma 100
Patients and methods 101
Results 101
Discussion 102
References 102
Chapter 21. Ulex europeus 1 : a tool to study vascular endothelium 104
Introduction 104
Material and methods 104
Results 105
Discussion 105
References 107
Chapter 22. NK-cells and nervous tissue share a common antigen 108
References 109
Chapter 23. Immunocytochemistry at the electron microscopic level: a new routine technique 112
Methods 112
Results 112
Discussion 113
References 113
Part III: Immunocompetent cells: function and recognition 116
Chapter 24. The IEM techniques in immunodermatology 118
Introduction 118
Materials and methods 118
Results and discussion 119
References 120
Chapter 25. Identification and functions of human Langerhans and epidermal indeterminate cells participating in the in vitro generation of alloreactive human cytotoxic 
122 
Material and methods 122
Results 124
Discussion 124
Acknowledgements 125
References 125
Chapter 26. Human Langerhans cells in in vitro systems: epidermal cell culture, skin explants and skin grafts onto 'nude' mice 126
Materials and methods 126
Results 127
Discussion 128
References 128
Chapter 27. Ultrastructural and quantitative evaluation of HLA-DR antigen densities of Langerhans cells 
130 
Introduction 130
Material and methods 130
Results 131
Discussion 131
Acknowledgements 133
References 133
Chapter 28. A novel cell population within mouse epidermis 134
Acknowledgements 137
References 137
Chapter 29. S22 antibody: a new marker for mononuclear phagocytes in dermatopathology 138
Introduction 138
Materials and methods 138
Results 138
Discussion 139
References 139
Chapter 30. Heterogeneity of Sézary cells. Multiparameter approach in two cases 140
Materials and methods 140
Results and comment 141
References 142
Chapter 31. Longitudinal study of surface antigen pattern in cutaneous T-cell lymphomas 144
References 145
Chapter 32. Cytochemical and immunological findings in cutaneous multilobated cell lymphoma 146
Materials and methods 146
Results and comment 146
References 148
Chapter 33. Lymphomatoid papulosis: its relationship with mycosis fungoides and Hodgkin's disease 150
Introduction 150
Lymphomatoid papulosis and Hodgkin's disease 152
Lymphomatoid papulosis and mycosis fungoides 153
Pathogenetic mechanisms in mycosis fungoides, Hodgkin's disease and lymphomatoid papulosis: 
153 
References 154
Chapter 34. Morphological recognition of 
156 
References 160
Chapter 35. Natural killer cells in skin pathology 162
Introduction 162
Materials and methods 162
Results 163
Discussion 163
References 168
Chapter 36. Influence of lymphocytes from patients with systemic sclerosis on cultured fibroblasts 170
Method 170
Results 172
Discussion 172
Acknowledgements 173
References 173
Chapter 37. Erythema fixum: a histological and an immunoperoxidase study using monoclonal antibodies 176
Patients and methods 176
Results 176
Discussion 178
References 178
Chapter 38. Immunohistological analysis of dermal leprous granulomas 180
Patients 181
Methods 181
Results and discussion 181
Conclusion 182
Acknowledgements 182
References 183
Chapter 39. A quantitative labelled antibody study of the evolving patterns of T cell subsets in lichen planus 184
Introduction 184
Materials and methods 184
Results 184
Discussion 187
References 187
Chapter 40. Plasma cells accumulating around epidermal neoplasias. Immunoenzymatic staining of paraffin sections 188
Introduction 188
Materials and method 188
Results 190
Discussion 191
References 191
Chapter 41. Immunoglobulin demonstration in circumorificial plasmacytosis 194
Material and Methods 194
Results 194
Discussion 194
References 195
Chapter 42. Immunocytochemical and electron microscopic observations of Langerhans cells in psoriasis before and during etretinate therapy 198
Introduction 198
Materials and methods 198
Results 199
Discussion 201
References 202
Chapter 43. Epidermal T lymphocytes and HLA-DR expression in psoriasis 204
Introduction 204
Methods 204
Results 204
Discussion 205
Reference 205
Chapter 44. The significance of antigen presenting cells in psoriasis 206
Introduction 206
Materials and methods 207
Results 207
Discussion 208
References 208
Chapter 45. Stimulation of T lymphocytes by isolated autologous or allogeneic human epidermal cells 210
Introduction 210
Materials and methods 210
Results 211
Discussion 212
References 214
Chapter 46. Production of lipoxygenase products of arachidonic acid by isolated human epidermal cells 216
Introduction 216
Materials and methods 216
Results 217
Discussion 218
Acknowledgements 219
References 219
Chapter 47. Morphological changes in polymorphonuclear leucocytes (PMN) with and without chemotaxic stimulation are modulated by ferritin-labelled lectins 222
References 224
Chapter 48. Modulation of polymorphonuclear leucocyte (PMN) chemotaxis and Superoxide anion production by wheat germ agglutinin (WGA) in skin diseases with PMN hyper-responsiveness 226
Reference 228
Chapter 49. Study of microphage functions in lichen ruber planus 230
References 231
Chapter 50. Functional activity of granulocytes from patients with neutrophilic dermatoses 232
References 233
Part IV: Vasculitis and autoimmune disease 234
Chapter 51. Role of platelet activating factor (Paf-acether) in the pathogenesis of vasculitis 236
Introduction 236
Subjects and methods 236
Results 236
Discussion 238
References 239
Chapter 52. Cutaneous vascular immunofluorescence: a sensitivity and specificity study 240
Methods 240
Results 241
Discussion 242
Conclusion 243
References 243
Chapter 53. Immuno-and histopathology of the skin in patients with rheumatoid arthritis 246
Introduction 246
Materials and methods 246
Results 247
Discussion 249
Acknowledgements 250
References 250
Chapter 54. Circulating immune complexes containing IgG anti-gliadin antibody in dermatitis herpetiformis detected by sucrose density gradient centrifugation and subsequent serological analysis 252
Introduction 252
Patients and Sera 252
Methods 253
Results 253
Discussion 255
References 255
Chapter 55. Microfibrils of elastic fibres as a major site of IgA deposition in dermatitis herpetiformis: an immunofluorescence and immunoelectron microscopical study 258
Introduction 258
Materials and methods 258
Results 258
Discussion 258
Acknowledgements 260
References 260
Chapter 56. Mixed immunodermatological characteristics of pemphigoid and dermatitis herpetiformis 262
Introduction 262
Case presentation 263
Comments 263
References 265
Chapter 57. The spectrum of linear IgA dermatoses 266
Chronic bullous disease of childhood 266
Linear IgA disease of adults 267
Transitional cases (chronic bullous disease of childhood to linear IgA disease of adults) 268
Childhood cicatricial pemphigoid with linear IgA deposits 269
Cicatricial pemphigoid 269
Discussion 269
References 270
Chapter 58. Paternal responsibility for herpes gestationis 272
Introduction 272
The effect of a change in sexual consort 272
Herpes gestationis and trophoblastic tumours 272
HLA 
272 
Spared pregnancies 273
Discussion 274
References 274
Chapter 59. Suppressor cell functions in pemphigus patients 276
References 277
Chapter 60. Radioimmunoassay to study pemphigus antibodies 280
References 281
Chapter 61. T-cell subsets and Langerhans cells in cutaneous lupus erythematosus 282
Introduction 282
Patients 283
Methods 283
Results 283
Discussion 286
Acknowledgements 286
References 286
Chapter 62. New evidence pertaining to the mechanism of cutaneous lupus erythematosus 288
Chapter 63. Serological profiles as immunological markers for different clinical presentations of lupus erythematosus and scleroderma 292
Materials and methods 292
Results 292
Discussion 294
Acknowledgements 294
References 294
Chapter 64. Antibodies to nuclear organelles occur in scleroderma and relate to clinical pattern 296
Introduction 296
Methods 296
Results 296
Discussion 297
References 298
Chapter 65. Treatment of alopecia areata with diphencyprone induces hair regrowth and affects the composition of peribulbar infiltrates 300
Induction of hair regrowth by diphencyprone 300
Influence of diphencyprone on the peribulbar infiltrate 302
OKT4/OKT8 ratio in the peribulbar infiltrates of untreated alopecia areata 302
OKT4/OKT8 ratio in the peribulbar infiltrates of alopecia areata treated with diphencyprone 302
Demonstration of OKT6 
302 
Discussion 307
Acknowledgement 307
References 307
Chapter 66. Immunopathology of bowel bypass disease 308
References 309
Chapter 67. Does IgM 
312 
Further reading 312

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Contributors

A.R. Ahmed,     Cutaneous Immunofluorescence Program, Division of Dermatology, UCLA School of Medicine, Los Angeles, California, USA

M.H. Allen,     Laboratory of Applied Dermatopathology, Guy’s Hospital, London

P.L. Amlot,     Department of Medicine, Guy’s Hospital, London

C.B. Archer,     Department of Dermatology, Guy’s Hospital, London

F. Ayala,     Associate Professor of Dermatology, Department of Dermatology, 2nd School of Medicine, University of Naples, Italy

Marie Anne Bach,     Immunopathology Unit, Institut Pasteur, Paris, France

B.S. Baker,     Dermatology Department, St Mary’s Hospital, London

C. Berger,     Department of Dermatology, Columbia University, New York, USA

E. Berti,     1st Department of Dermatology, University of Milan, Milan, Italy

B. Bhogal,     Department of Immunofluorescence, St John’s Hospital for Diseases of the Skin, London

J.R. Bjerke,     Department of Dermatology, University of Bergen, Norway

M.M. Black,     Department of Immunofluorescence, St John’s Hospital for Diseases of the Skin, London

E. Bonifazi,     Department of Dermatology, University of Bari, Italy

K. Bork,     Universitäts-Hautklinik, Mainz, West Germany

J.D. Bos,     Department of Dermatology, University of Amsterdam, Academic Medical Centre, Amsterdam, The Netherlands

P.A. Botham,     Immunology Group, Biomedical Science Section, Central Toxicology Laboratory, Imperial Chemical Industries, Macclesfield, Cheshire

A. Bourland,     Department of Dermatology, Catholic University of Louvain, Brussels, Belgium

O. Braun-Falco,     Dermatologische Klinik der Ludwig-Maximilians-Universität München, West Germany

J. Brochier,     Unité INSERM 80, Hôpital E. Herriot, Lyon, France

Eva-B. Bröcker,     Universitäts-Hautklinik, Münster, West Germany

J. Brüggen,     Universitäts-Hautklinik, Münster, West Germany

B.E. Buck,     Department of Pathology, University of Miami, Florida, USA

G. Budillon,     Associate Professor of Gastroenterology, Centre of Hepatology, 2nd School of Medicine, Naples, Italy

G. Burg,     Dermatologische Klinik der Ludwig-Maximilians-Universität München, West Germany

T.K. Burnham,     Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA

J.G. Camarasa,     Professor of Dermatology, Autonomous University, Barcelona, Spain

R. Caputo,     1st Department of Dermatology, University of Milan, Italy

M.M. Carr,     Research Fellow, Department of Dermatology, University of Edinburgh

A. Cats,     Department of Rheumatology, University of Leiden, The Netherlands

S. Cavicchini,     1st Department of Dermatology, University of Milan, Italy

D.V. Chapman,     Department of Histopathology, St Thomas’ Hospital, London

E. Christophers,     Department of Dermatology, University of Kiel, West Germany

J.C. Claudatus,     Department of Dermatology, University of Bari, Italy

G. Cordier,     Unité INSERM 80, Clinique Néphrologique, Hôpital E. Herriot, Lyon, France

F. Cottenot,     Dermatology Department, Hôpital St-Louis, Paris, France

Marie Cramers,     Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark

R. Cuomo,     Assistant in Gastroenterology, Centre of Hepatology, 2nd School of Medicine, Naples, Italy

M. Cusini,     1st Department of Dermatology, University of Milan, Italy

Beate M. Czarnetzki,     Department of Dermatology, Universitäts-Hautklinik, Münster, West Germany

J. Czernielewski,     Department of Cell Biology, CIRD, Sophia Antipolis, Valbonne, France

M.R. Daha,     Department of Nephrology, University Hospital of Leiden, The Netherlands

M.C.J.M. De Jong,     Department of Dermatology, State University Hospital, Groningen, The Netherlands

G.F. Del Prete,     Department of Clinical Immunology, University of Florence, Italy

M. Demarchez,     Department of Cell Biology, CIRD, Sophia Antipolis, Valbonne, France

J.A.M. De Nijs,     Zeister Hospital, Zeist, The Netherlands

G. De Panfilis,     Associate Professor, Department of Experimental Dermatology, University of Parma, Italy

U. Detmar,     Department of Dermatology, University of Munich, West Germany

C. Dezutter-Dambuyant,     Unité INSERM 209, Clinique Dermatologique, Hôpital E. Herriot, Lyon, France

D. Djawari,     Department of Dermatology, University of Erlangen-Nürnberg, Erlangen, West Germany

K. Donhuijsen,     Institute of Pathology, University of Essen, West German Tumour Centre, Essen, West Germany

L. Dubertret,     Dermatology Laboratory, Hôpital Henri Mondor, Creteil, Paris, France

R. Edelson,     Department of Dermatology, Columbia University, New York, USA

H. Ely,     Assistant Clinical Professor of Dermatology, University of California at Davis, Davis, California, USA

J.A. Emsbroek,     Department of Dermatology, University of Amsterdam, Academic Medical Centre, Amsterdam, The Netherlands

A. Fattorossi,     2nd Dermatology Clinic, Via Della Pergola, Florence, Italy

M. Faure,     Unité INSERM 109, Clinique Dermatologique, Hôpital E. Herriot, Lyon, France

Beatrice Flageul,     Dermatology Department, Hôpital St-Louis, Paris, France

M. Fosse,     Dermatology Laboratory, Hôpital Henri Mondor, Creteil, Paris, France

A. Frappez,     Unité INSERM 209, Clinique Dermatologique, Hôpital E. Herriot, Lyon, France

W. Freytag,     Department of Dermatology, Universitäts-Hautklinik, Münster, West Germany

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Produkt-Details

• Erscheint lt. Verlag: 28.6.2014
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• ISBN-10: 1-4831-9200-8 / 1483192008
• ISBN-13: 978-1-4831-9200-0 / 9781483192000