Handbook of Tuberculosis

Stefan H. E. Kaufmann, Paul van Helden, Eric Rubin, Warwick J. Britton (Herausgeber)

Buch | Hardcover

1350 Seiten

2008 | 1. Auflage
Wiley-VCH (Verlag)
978-3-527-31683-0 (ISBN)

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Coinciding with the first TB therapies to enter clinical trials in 60 years, this is the most comprehensive account of the latest developments in clinical, therapeutic and basic research into the disease, presented by the most prolific of all researchers in the field.Divided into three clearly structured volumes, the first deals with molecular biology and biochemistry of the pathogen, including genetics and genomics, as well as drug design. The second volume covers cell biology, immunology and vaccine development, while the third is devoted to epidemiology and clinical approaches, including drug resistance, veterinary aspects and clinical field trials.With one new infection worldwide every second, this is an essential reference for bacteriologists, immunologists, pathologists and pathophysiologists, molecular and cell biologists, as well as those working in the pharmaceutical industry.

Prof. Dr. Stefan H.E. Kaufmann is Founding Director of the Max Planck Institute for Infection Biology, Berlin. He has published more than 600 scientific articles and is member of numerous scientific societies and committees e.g. current President of the European Federation of Immunological Societies, and Chair of the Immunology division of the American Society of Microbiology. He has won numerous prestigious awards including the Scientific Prize of Smith Kline Beecham and the Pettenkofer Prize. Paul van Helden is Professor of Medical Biochemistry at Stellenbosch University, South Africa. He is Director of Laboratory Research for the Desmond Tutu TB Centre. He is a past president of the SA Society of Biochemistry and Molecular Biology, and has received the Gold medal of this society. Eric Rubin is Professor of Immunology and Infectious Diseases at the Harvard School of Public Health. He carried out both his MD and PhD work at Tufts University. Warwick Britton is Professor of Medicine at the University of Sydney, Australia. He serves as Chairman of the State Committee for the Australian Society of Clinical Immunology and Allergy.

VOLUME 1: MOLECULAR BIOLOGY AND BIOCHEMISTRY
Tuberculosis - Molecular Genetics and Biochemistry: Introduction
Biochemistry of the Cell Wall
Glycolipids and Polyketides of M. tuberculosis
Physiology of M. tuberculosis
Nutrient Transport
Iron Uptake by M. tuberculosis
Protein Transport
PE and PPE Gene Family Members in M. tuberculosis
Virulence/Persistence Mechanisms of M. tuberculosis
Genomics
Transcriptomics and Transcriptional Regulation
Proteomics of M. tuberculosis
Structure
Molecular Mechanisms of Dormancy and Resuscitation
M. tuberculosis in the Phagosome
Molecular Mechanisms of Drug Resistance of M. tuberculosis
Experimental Genetics of M. tuberculosis
Molecular Evolution of Mycobacteria

VOLUME 2: IMMUNOLOGY AND CELL BIOLOGY
Introduction: Immunity to M. tuberculosis and BCG
Recognition Receptors and Phagocytosis for M. tuberculosis
Transcriptional Response of Macrophages and Dendritic Cells to M. tuberculosis
Dendritic Cells and Antigen Presentation
Killing Mechanisms of the Host Against M. tuberculosis
Manipulation of the Macrophage Response
Conventional T Cells and their Antigenic Repertoire
Unconventional T Cells
Cytokines in Tuberculosis
Antibodies in Tuberculosis
Pathology
Maintenance of Latent Infection with Correlates of Protective Immunity
Genetics of Resistance (mouse and man)
HIV/TB Interactions
Novel Vaccination Strategies Against Tuberculosis
Experimental Animal Models of Tuberculosis

VOLUME 3: CLINICS DIAGNOSTICS THERAPY AND EPIDEMIOLOGY
Clinics Diagnostics Therapy Epidemiology: Introduction
Global Epidemiology of Tuberculosis
Surveillance Studies and Interpretation
Molecular Epidemiology of M. tuberculosis
Diagnosis of M. tuberculosis: Clinical
Clinical Disease (with and without HIV)
Management of Tuberculosis Patients
Chemotherapy
New Drugs and Clinical Drug Trials
Latency
Drug Resistance in Clinical Context
Novel Drug Treatment Strategies - Co-infections
Modeling
BCG Vaccination

"...Edited and written by the leading experts in the field [this three volume handbook] is the most comprehensive book on this topic available..." -Anticancer Research

Erscheint lt. Verlag	13.2.2008
Sprache	englisch
Maße	170 x 240 mm
Gewicht	2755 g
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Biowissenschaften • Cell & Molecular Biology • Cell & Molecular Biology • Chemie • Chemistry • clinical microbiology • Klinische Mikrobiologie • Life Sciences • Medical Science • Medizin • Medizinische Mikrobiologie • Microbiology & Virology • Microbiology & Virology • Mikrobiologie • Mikrobiologie u. Virologie • Pharmaceutical & Medicinal Chemistry • Pharmaceutical & Medicinal Chemistry • Pharmazeutische u. Medizinische Chemie • Tuberkulose • Zell- u. Molekularbiologie
ISBN-10	3-527-31683-3 / 3527316833
ISBN-13	978-3-527-31683-0 / 9783527316830
Zustand	Neuware