Left-Right Asymmetry in Vertebrate Development

M.L. López-Gracia, M.A. Ros (Autoren)

Buch | Softcover

XII, 126 Seiten

2006 | 2007
Springer Berlin (Verlag)
978-3-540-36347-7 (ISBN)

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Externally the vertebrate body plan presents a bilateral symmetry in relation to the midline. However, inside the body the distribution of the visceral organs follows a very particular pattern that is not symmetrical in relation to the midline. The last 10 years have seen remarkable advances in our understanding of how the internal asymmetries typical of the vertebrate body are established and controlled. The use of different development models has permitted to uncover fascinating ways of creating asymmetry, like the activity of the nodal cilia. A host of studies has also unravelled the involvement of many genes in the left right patterning pathway. Based on this knowledge the genetic basis of human laterality defects are beginning to be revealed. It is a major challenge now to understand how all these genes control left right development as well as the complex set of interactions established between them.

Establishment of Left-Right Asymmetry.- Signaling Pathways with a Predominant Role in Left-Right Patterning.- Mouse Models of Laterality.- Genetics of Human Alterations of Organ Situs.- Concluding Remarks.

Erscheint lt. Verlag	11.12.2006
Reihe/Serie	Advances in Anatomy, Embryology and Cell Biology
Zusatzinfo	XII, 126 p. 16 illus., 13 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	412 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
Themenwelt	Naturwissenschaften ► Biologie
Schlagworte	Development • Heart development • Heterotaxia • Kartagener • Left-right axis • Left-right patterning • primary ciliary dyskinesia, PCD • Situs ambiguus • Situs inversus
ISBN-10	3-540-36347-5 / 3540363475
ISBN-13	978-3-540-36347-7 / 9783540363477
Zustand	Neuware