Left-Right Asymmetry in Vertebrate Development (eBook)

M.L. López-Gracia, M.A. Ros (Autoren)

eBook Download: PDF

2007 | 2007
XII, 126 Seiten
Springer Berlin (Verlag)
978-3-540-36348-4 (ISBN)

Infos

Externally the vertebrate body plan presents a bilateral symmetry in relation to the midline. However, inside the body the distribution of the visceral organs follows a very particular pattern that is not symmetrical in relation to the midline. The last 10 years have seen remarkable advances in our understanding of how the internal asymmetries typical of the vertebrate body are established and controlled. The use of different development models has permitted to uncover fascinating ways of creating asymmetry, like the activity of the nodal cilia. A host of studies has also unravelled the involvement of many genes in the left right patterning pathway. Based on this knowledge the genetic basis of human laterality defects are beginning to be revealed. It is a major challenge now to understand how all these genes control left right development as well as the complex set of interactions established between them.

Inhalt

List of Contents 6
Acknowledgements 7
Abbreviations 8
1 Introduction 11
2 Establishment of Left–Right Asymmetry 23
3 Signaling Pathways with a Predominant Role in Left–Right Patterning 45
4 Mouse Models of Laterality 54
5 Genetics of Human Alterations of Organ Situs 80
6 Concluding Remarks 90
References 106
1 Appendix 125
2 Glossary 129
Subject Index 133

Produkt-Details

• Erscheint lt. Verlag: 3.2.2007
• Reihe/Serie: Advances in Anatomy, Embryology and Cell Biology
• Reihe/Serie: Advances in Anatomy, Embryology and Cell Biology
• Zusatzinfo: XII, 126 p. 16 illus., 13 illus. in color.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Studium
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Development • Heart development • Heterotaxia • Kartagener • Left-right axis • Left-right patterning • primary ciliary dyskinesia, PCD • Situs ambiguus • Situs inversus
• ISBN-10: 3-540-36348-3 / 3540363483
• ISBN-13: 978-3-540-36348-4 / 9783540363484