Peptide Solvation and H-bonds

Robert Baldwin, David James Baker (Herausgeber)

Buch | Hardcover

312 Seiten

2006
Academic Press Inc (Verlag)
978-0-12-034272-3 (ISBN)

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Addresses the role of peptide backbone solvation in the energetics of protein folding. This work discusses how to solve the problem of protein structure prediction, and addresses the quantitation of the energetics of folding. It focuses on modeling and computation, and also challenges the longstanding and basic assumptions of structural biology.

Former Senior Lecturer, Willesden College of Technology, London

Preface: New Directions in the Study of Peptide H-bonds and Peptide Solvation; Potential Functions for Hydrogen Bonds in Protein Structure Prediction and Design; Backbone-Backbone H-Bonds Make Context Dependent Contributions to Protein Folding Kinetics and Thermodynamics: Lessons from Amide-to-Ester Mutations; Modeling Polarization in Proteins and Protein-Ligand Complexes: Methods and Preliminary Results; Hydrogen Bonds in Molecular Mechanics Force Fields; Resonance Character of Hydrogen-Bonding Interactions in Water and Other H-Bonded Species; How Hydrogen Bonds Shape Membrane Protein Structure; Peptide and Protein Folding and Conformational Equilibria: Theoretical Treatment of Electrostatics and Hydrogen Bonding with Implicit Solvent Models; Thermodynamics of α-Helix Formation; The Importance of Cooperative Interactions and A Solid State Paradigm to Proteins – What Peptide Chemists Can Learn from Molecular Crystals

Erscheint lt. Verlag	15.3.2006
Reihe/Serie	Advances in Protein Chemistry
Verlagsort	San Diego
Sprache	englisch
Maße	152 x 229 mm
Gewicht	630 g
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	0-12-034272-3 / 0120342723
ISBN-13	978-0-12-034272-3 / 9780120342723
Zustand	Neuware