Proteins

A Structural Biology Perspective

Jia-huai Wang (Autor)

Buch | Softcover

378 Seiten

2024
Academic Press Inc (Verlag)
978-0-323-99893-2 (ISBN)

Infos

Proteins: A Structural Biology Perspective explains how advances in modern physics fueled the birth of structural biology and modern molecular biology in the early to mid 20th century. Scientifically rigorous and deeply informed by the author’s own 60-year career as a structural biologist, the book provides historical and personal accounts of how two generations of renowned scientists doggedly pursued their research projects to arrive at milestone achievements, while also covering basic aspects of protein structures and their evolution with a special focus on molecules at the surface of cells and viruses. Since 1962, when only a single structure for myoglobin had been determined at atomic resolution, the rapidly evolving field has grown exponentially to fill protein structure databases (PDB) worldwide with hundred thousands of structures for basic research and medical advancement. From “What is a Wave?” to “What Is Life?”, Proteins: A Structural Biology Perspective takes readers on a uniquely intimate journey through the past 100 years of protein science, while providing an up-to-the-minute assessment of successful structure prediction by AI models like AlphaFold and RoseTTAFold and where it’s all likely to lead. Outfitted with detailed illustrations and authoritative citations, this is a valuable resource for graduate students and young research scientists in biology and the medical sciences.

Autor

Jia-huai Wang is Associate professor at the Dana-Farber Cancer Institute, Harvard Medical School, USA. As a veteran structural biologist specialized in cell surface receptors functioning in immune system and nervous system he has around 140 peer-reviewed papers published, including 11 articles in Nature, Science and Cell. When in China, in the early 1970’s, he was the team member which determined the structure of insulin, one of the world’s first dozen protein structures solved. Since 1988 he has been working at Harvard. As a leading author, he has published a series of extremely important structures, such as the first virus structure CD4, the first cell adhesion interacting complex CD2/CD58, the ground-breaking preTCR-ligand interacting complex and the prototypical axon guidance cue netrin-1 interactions. He has a deep understanding about protein structure and how a protein functions.

Inhalt

1. From “What is wave” to “What is life” to the booming structural biology 2. From a to b: The beginning of protein structure analyses 3. Proteins-in-modules and genes-in-pieces. How proteins evolve 4. How one structure has changed a field—the MHC molecules in cellular immunity 5. T cell receptors, the molecular bodyguard in ab T lymphocyte immunity 6. Protein-mediated cell-cell interactions in multicellular biology 7. How do viruses assemble and infect their host cells? 8. AlphaFold2, the successful prediction of three-dimensional protein structures and its impact on structural biology

Produkt-Details

• Erscheint lt. Verlag: 13.12.2024
• Verlagsort: Oxford
• Sprache: englisch
• Maße: 152 x 229 mm
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• ISBN-10: 0-323-99893-3 / 0323998933
• ISBN-13: 978-0-323-99893-2 / 9780323998932
• Zustand: Neuware