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Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis -

Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis

Paolo Beck-Peccoz (Herausgeber)

Buch | Hardcover
198 Seiten
2004
Springer-Verlag New York Inc.
978-1-4020-7807-1 (ISBN)
CHF 149,75 inkl. MwSt
Covers the scientific findings of the syndromes of hormone resistance in the HPT axis - thyroid hormone resistance and resistance to TSH action. This book covers the mechanisms of action of the various hormones, etiopathology of the syndromes, instruments for diagnosis, as well as the difficulties in managing these diseases.
The exponential growth in our knowledge on the pathophysiology of hypothalamic-pituitary-thyroid axis and, in particular, of thyroid hormone action, largely stems from the studies on the various syndromes of resistance to the hormones involved in the function of the axis. These syndromes essentially encompass two forms, i. e. the resistance to thyroid hormones and that to TSH action. The contribution of molecular biology has been fundamental in understanding the etiology of these different thyroid disorders and led to the discovery of new pathogenetic mechanisms, e. g. the dominant negative effects of a mutant protein on the normal one. In this book, I have assembled an internationally renewed group of experts devoted to the studies of both basic and clinical thyroidology. Taking the syndromes of resistance as a template, the novelties on the mechanisms of action of the various hormones, the etiopathogenesis of the syndromes, the instruments for the diagnosis, as well as the pitfalls in managing these diseases, are deeply revisited. The insights from different animal models are discussed, with particular focus on tissue specific action of thyroid hormones, as well as on the still enigmatic mechanism of negative feedback control of thyroid hormones on TSH secretion and the different etiologic mechanisms causing thyroid hormone resistance in patients without mutations in the thyroid hormone receptor ~. The role of the structure of thyroid hormone and TSH receptors in designing agonist or antagonist molecules is extensively debated. Moreover, new forms of congenital or acquired resistance to thyroid hormones are presented.

1. Molecular basis of thyroid hormone action.- 2. Tissues specific action of thyroid hormones: insights from knock out animal models.- 3. Learning from nature’s experiments on the thyroid hormone receptor; X-ray structures of RTH mutant ligand-binding domains.- 4. Molecular pathogenesis of resistance to thyroid hormone.- 5. Syndromes of resistance to thyroid hormone: clinical aspects.- 6. Resistance to thyroid hormone in the absence of mutations in the thyroid hormone receptor genes.- 7. Lessons learned from TR-? mutant mice.- 8. Towards the rational design of hormone analogs which complement receptor mutations.- 9. Multi-factorial regulation of in vivo action of TR? mutants. Lessons learned from RTH mice with a targeted mutation in the TR? gene.- 10. The effect of vitamin A, retinoids and retinoid receptors on the hypothalamic-pituitary-thyroid axis.- 11. Pituitary resistance to thyroxine action due to a defect in the type 2 deiodinase.- 12. Different forms of resistance to thyrotropin (TSH) action.

Reihe/Serie Endocrine Updates ; 22
Zusatzinfo 45 Illustrations, black and white; VIII, 198 p. 45 illus.
Verlagsort New York, NY
Sprache englisch
Maße 155 x 233 mm
Themenwelt Medizinische Fachgebiete Innere Medizin Diabetologie
Medizinische Fachgebiete Innere Medizin Endokrinologie
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zoologie
ISBN-10 1-4020-7807-2 / 1402078072
ISBN-13 978-1-4020-7807-1 / 9781402078071
Zustand Neuware
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