Metalloenzymes

From Bench to Bedside

Claudiu T. Supuran, William Alexander Donald (Herausgeber)

Buch | Softcover

634 Seiten

2023
Academic Press Inc (Verlag)
978-0-12-823974-2 (ISBN)

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Metalloenzymes: From Bench to Bedside offers a thorough overview of metalloenzymes, spanning biochemical and structural features, pharmacology, and biotechnological applications. After a brief overview, international experts in the field discuss a wide range of magnesium, calcium, zinc, manganese, nickel, iron, copper, cadmium, molybdenum, and tungsten enzymes, along with catalytic roles within their active sites. With a uniform approach throughout, each chapter includes the structure and function of the enzyme, physiologic and pathologic roles, inhibitors and activators of the enzyme (and their design), and clinical agents or compounds applied in medicine and drug discovery. This book enables scientists across academia and industry to adopt ongoing metalloenzyme research, and continuous discovery of novel metalloenzymes, in new life science studies and clinical applications.

Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields. Dr. William Alexander Donald is an academic and research group leader in the School of Chemistry at the University of New South Wales, Australia. His research interests include carbonic anhydrases, coordination chemistry, and the development of bioanalytical methodologies for improving drug discovery and development. He has published more than 120 papers in these fields.

1. Introduction to metalloenzymes

Section II 2. Magnesium and calcium-containing enzymes

Section III 3. Zinc enzymes

Section IV. Other metalloenzymes 4. Manganese enzymes 5. Nickel enzymes 6. Iron enzymes (heme-containing) 7. Iron enzymes (non-heme containing, Fe(II) or Fe(III) proteins) 8. Copper enzymes 9. Cadmium enzymes 10. Molybdenum enzymes 11. Tungsten-containing enzymes

Erscheinungsdatum	09.09.2023
Zusatzinfo	150 illustrations (100 in full color); Illustrations
Verlagsort	San Diego
Sprache	englisch
Maße	191 x 235 mm
Gewicht	1720 g
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	0-12-823974-3 / 0128239743
ISBN-13	978-0-12-823974-2 / 9780128239742
Zustand	Neuware