Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals

Yunjiao Zhang (Autor)

Buch | Softcover

156 Seiten

2023 | 1st ed. 2022
Springer Verlag, Singapore
978-981-16-8168-4 (ISBN)

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This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.

Introduction.- Phage display identifies a specific high-affinity binding peptide RE-1 for lanthanide (LN) nanomaterials.- RE-1 forms a stable coating layer on the surface of upconversion nanoparticles / nanocrystals (UCN).- Reduction of UCN sedimentation and nanomaterial–cell interaction by RE-1 coating.- RE-1 coating abrogates autophagy induction and toxicity for UCN in vitro and in vivo.- Enhancement of cell interaction and autophagy induction by coating with RE-1-RGD.-Conclusion and prospect.

Erscheinungsdatum	11.01.2023
Reihe/Serie	Springer Theses
Zusatzinfo	66 Illustrations, color; 12 Illustrations, black and white; XV, 156 p. 78 illus., 66 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Naturwissenschaften ► Biologie ► Allgemeines / Lexika
	Naturwissenschaften ► Biologie ► Zellbiologie
	Technik ► Maschinenbau
	Technik ► Umwelttechnik / Biotechnologie
Schlagworte	autophagy-inducing activity • cell interaction and toxicity • diagnostic and therapeutic applications • lanthanide (LN) nanocrystals • non-covalent binding peptides • phage display technology • synthetic peptide RE-1 • upconversion nanoparticles/nanocrystals (UCN)
ISBN-10	981-16-8168-6 / 9811681686
ISBN-13	978-981-16-8168-4 / 9789811681684
Zustand	Neuware