Cellular Lipid in Health and Disease

Buch | Softcover

450 Seiten

2023
Academic Press Inc (Verlag)
978-0-323-95582-9 (ISBN)

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Cellular Lipid in Health and Disease presents a comprehensive and systematic coverage of the various roles lipids play in human biology. The book is organized in four parts, covering the foundational concepts of lipid biology and the therapeutic opportunities they present. Sections cover basic concepts of cellular lipid, the roles it plays in the cell, structure and physiology, regulation mechanisms, storage, and utilization; the organelles involved in lipid trafficking, metabolism in aging, cholesterol homeostasis, lipid droplets (LDs), and lipid oxidation; and the roles lipids play in specific disease states, including renal, metabolic, cardiovascular and fatty liver diseases.

Other conditions covered include cancer, neurodegenerative diseases, and the intricate relationship between cellular lipids and autophagy. Final sections cover therapeutic opportunities, including drug carrier systems, modeling lipid metabolism, and prevention therapeutics. This a complete reference targeted at graduate students and early career researchers in cell biology, biochemistry and pharmacology. Research physicians can also benefit from the foundational content and links to pathologies and therapeutic opportunities.

Dr. James M. Ntambi is Professor of Biochemistry and the Steenbock Professor of Nutritional Sciences, at the University of Wisconsin-Madison, as well as Adjunct Professor of Biological Chemistry at Johns Hopkins University School of Medicine. The focus of Dr. Ntambi's research is to understand the genetic regulation of metabolism, adipocyte biology, and differentiation. He is specifically interested in the genetic basis of obesity, cardiovascular disease, insulin resistance, and diabetes and how dietary factors, hormones, and environmental factors influence these disease states. Most recently, his team have genetically engineered mice that are born without the stearoyl-CoA desaturase gene-1, and found that these mice resist obesity, diabetes, and fatty liver disease. Dr. Ntambi also conducts research on obesity and diabetes and other non-communicable metabolic diseases in developing countries. Dr. Ntambi has published more than 180 scientific articles in such journals as Scientific Reports, PLoS ONE, Gastroenterology, and the Journal of Lipid Research.

I introduction to Cellular Lipid 1. Roles of lipid in the cell 2. Structural and Physiological roles 3. (bio)Physical properties of lipid bilayers 4. Lipid regulation mechanisms 5. Intracellular lipid storage and utilization

II Cellular Lipid Metabolism 6. Overview of organelles involved 7. Enzymes involved in lipid synthesis and remodelling 8. Cellular Lipid Trafficking 9. Lipid Metabolism in Aging 10. Cholesterol Homeostasis 11. Lipid droplets 12. Lipid Oxidation

III Cellular lipid roles in diseases 13. Renal Disease 14. Lipodystrophy 15. Obesity and Diabetes 16. Cardiovascular Disease 17. Fatty liver disease 18. Cancer 19. Neurodegenerative Diseases 20. Immune diseases 21. Autophagy 22. Lipids and Viruses

IV Therapeutic opportunities 23. Lipids as drug carrier systems 24. Drugs modeling lipid metabolism 25. Translational and preventive

Erscheint lt. Verlag	1.7.2023
Verlagsort	Oxford
Sprache	englisch
Maße	191 x 235 mm
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
Themenwelt	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	0-323-95582-7 / 0323955827
ISBN-13	978-0-323-95582-9 / 9780323955829
Zustand	Neuware